Efeitos histolíticos do ácido acetilsalicítico a 10% e 20% em linfonodos: estudo experimental em coelhos
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Data
2010-08-26
Autores
Batista, Rodrigo Peduti [UNESP]
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Editor
Universidade Estadual Paulista (Unesp)
Resumo
A alta incidência mundial do câncer o coloca como um grande problema de saúde pública, tanto em países desenvolvidos como em desenvolvimento. Suas particularidades, no que tange a malignidade, geram grandes problemas sociais e psicológicos nos indivíduos acometidos. O câncer é responsável por mais de 6 milhões de óbitos por ano, chegando a 12% de todas as causas no mundo. Grande número de pacientes já apresenta metástases à distância e em linfonodos adjacentes ao tumor no diagnóstico inicial. Assim como as metástases hepáticas, a disseminação linfonodal das neoplasias malignas entra como um dos principais fatores de prognóstico e recidiva das neoplasias. A ressecção cirúrgica linfonodal é considerada a principal modalidade terapêutica curativa, porém, em algumas situações, reveste-se de fatores limitantes, tais como número e localização dos linfonodos comprometidos e principalmente a aderência a órgãos e estruturas adjacentes. Ao considerar tais dificuldades e características da terapêutica das metástases linfonodais, novas opções de tratamento necessitam ser desenvolvidas. Para que estas novas opções terapêuticas tenham aplicabilidade é de se esperar que tenham uma boa taxa de eficácia, um baixo custo, pouca freqüência de efeitos colaterais e que sejam de fácil execução. Neste sentido, seguindo a linha de pesquisa do Laboratório de Cirurgia Experimental da Faculdade de Medicina de Botucatu- FMB/UNESP surgiu a ideia de avaliação dos efeitos do ácido acetilsalicílico em linfonodos normais em animais de experimentação para posterior embasamento e uso em linfonodos acometidos por tumor. No presente trabalho foram utilizadas as soluções bicarbonatadas de ácido acetilsalicílico a 10% e 20% injetadas em linfonodos mesentéricos de coelhos sadios, sendo seus efeitos avaliados em 24 horas e também em 7 dias. Nos grupos avaliados...
The high incidence of cancer worldwide poses as a great public health problem both in developed and developing countries. Its peculiarities with respect to malignancy generate great social and psychological problems for affected individuals. Cancer is responsible for more than six million deaths per year reaching 12% of all causes in the world. A large number of patients already have distant metastases in lymph nodes adjacent to the tumor at initial diagnosis. As well as liver metastases, the lymph node spread of malignant neoplasm comes in as one of the major factors of prognostic and recurrence of neoplasm. The lymph node resection surgery is considered the main type of treatment for cure but in some situations it presents limiting factors such as number and location of lymph nodes involved and especially the adherence to adjacent organs and structures. Considering such difficulties and therapeutic characteristics of lymph node metastases, new treatment options need to be developed. In order to have applicability it’s expected that these new treatment options have effectiveness, low cost, low frequency of side effects and they should be easily executed. Following the line of research at the Laboratory of Experimental Surgery of Botucatu School of Medicine FMB / UNESP, it came up the idea of evaluating the effects of aspirin in normal lymph nodes in experimental animals on a trial basis for later use in lymph nodes affected by tumor. The present work used bicarbonate acetylsalicylic acid solution at 10% and 20% injected into lymph nodes of healthy rabbits and had its effects evaluated at 24 hours and at 7 days. In the groups evaluated at 24 hours it was observed extensive necrosis and hemorrhage, a significant increase in apoptosis throughout the lymph node with medullary sinuses enlargement and an increase in germinal centers. In the groups evaluated at 7 days of solution... (Complete abstract click electronic access below)
The high incidence of cancer worldwide poses as a great public health problem both in developed and developing countries. Its peculiarities with respect to malignancy generate great social and psychological problems for affected individuals. Cancer is responsible for more than six million deaths per year reaching 12% of all causes in the world. A large number of patients already have distant metastases in lymph nodes adjacent to the tumor at initial diagnosis. As well as liver metastases, the lymph node spread of malignant neoplasm comes in as one of the major factors of prognostic and recurrence of neoplasm. The lymph node resection surgery is considered the main type of treatment for cure but in some situations it presents limiting factors such as number and location of lymph nodes involved and especially the adherence to adjacent organs and structures. Considering such difficulties and therapeutic characteristics of lymph node metastases, new treatment options need to be developed. In order to have applicability it’s expected that these new treatment options have effectiveness, low cost, low frequency of side effects and they should be easily executed. Following the line of research at the Laboratory of Experimental Surgery of Botucatu School of Medicine FMB / UNESP, it came up the idea of evaluating the effects of aspirin in normal lymph nodes in experimental animals on a trial basis for later use in lymph nodes affected by tumor. The present work used bicarbonate acetylsalicylic acid solution at 10% and 20% injected into lymph nodes of healthy rabbits and had its effects evaluated at 24 hours and at 7 days. In the groups evaluated at 24 hours it was observed extensive necrosis and hemorrhage, a significant increase in apoptosis throughout the lymph node with medullary sinuses enlargement and an increase in germinal centers. In the groups evaluated at 7 days of solution... (Complete abstract click electronic access below)
Descrição
Palavras-chave
Metastase - Tratamento - Estudos experimentais, Acetylsalicylic acid
Como citar
BATISTA, Rodrigo Peduti. Efeitos histolíticos do ácido acetilsalicítico a 10% e 20% em linfonodos: estudo experimental em coelhos. 2010. 84 f. Dissertação (mestrado) - Universidade Estadual Paulista, Faculdade de Medicina de Botucatu, 2010.