Now showing items 1-10 of 29
Diapocynin versus apocynin as pretranscriptional inhibitors of NADPH oxidase and cytokine production by peripheral blood mononuclear cells
(Biochemical and Biophysical Research Communications, 2010-03-12) [Artigo]
Apocynin has been extensively used as an inhibitor of NADPH oxidase (NOX) in many experimental models using phagocytic and non-phagocytic cells. Currently, there is some controversy about the efficacy of apocynin in ...
2-Bromo-1,4-naphthoquinone: a potentially improved substitute of menadione in Apatone therapy
(Brazilian Journal of Medical and Biological Research, 2012-08-01) [Artigo]
Apatone™, a combination of menadione (2-methyl-1,4-naphthoquinone, VK3) and ascorbic acid (vitamin C, VC) is a new strategy for cancer treatment. Part of its effect on tumor cells is related to the cellular pro-oxidative ...
Caffeic Acid Phenethyl Ester: Consequences of Its Hydrophobicity in the Oxidative Functions and Cytokine Release by Leukocytes
(Evidence-based Complementary And Alternative Medicine, 2014-01-01) [Artigo]
Numerous anti-inflammatory properties have been attributed to caffeic acid phenethyl ester (CAPE), an active component of propolis. NADPH oxidases are multienzymatic complexes involved in many inflammatory diseases. Here, ...
Alkaloids extracted from Pterogyne nitens induce apoptosis in malignant breast cell line
(Tumor Biology, 2010-10-01) [Artigo]
In the present study, two alkaloids isolated from Pterogyne nitens, a plant native to Brazil, have been shown to induce apoptosis in human breast cancer cells. These compounds, pterogynine (PGN) and pterogynidine (PGD), ...
Ethyl Ferulate, a Component with Anti-Inflammatory Properties for Emulsion-Based Creams
(Molecules, 2014-06-01) [Artigo]
Ethyl ferulate (FAEE) has been widely studied due to its beneficial heath properties and, when incorporated in creams, shows a high sun protection capacity. Here we aimed to compare FAEE and its precursor, ferulic acid ...
Apocynin: Chemical and biophysical properties of a NADPH oxidase inhibitor
(Molecules, 2013-03-01) [Artigo]
Apocynin is the most employed inhibitor of NADPH oxidase (NOX), a multienzymatic complex capable of catalyzing the one-electron reduction of molecular oxygen to the superoxide anion. Despite controversies about its ...
4 '-Aminochalcones as novel inhibitor of the chlorinating activity of myeloperoxidase
(Planta Medica, 2012-08-01) [Resumo]
Bioactive Secondary Metabolites from Phomopsis sp., an Endophytic Fungus from Senna spectabilis
(Molecules, 2014-05-01) [Artigo]
Chemical investigation of an acetonitrile fraction from the endophytic fungus Phomopsis sp. led to the isolation of the new natural product 2-hydroxy-alternariol (7) together with the known compounds cytochalasins J (1) ...
Inhibitory Effect of Gallic Acid and Its Esters on 2,2 '-Azobis(2-amidinopropane)hydrochloride (AAPH)-Induced Hemolysis and Depletion of Intracellular Glutathione in Erythrocytes
(Journal of Agricultural and Food Chemistry, 2010-05-12) [Artigo]
The protective effect of gallic acid and its esters, methyl, propyl, and lauryl gallate, against 2,2'-azobis(2-amidinopropane)hydrochloride (AAPH)-induced hemolysis and depletion of intracellular glutathione (GSH) in ...
Effects of oxidation of lysozyme by hypohalous acids and haloamines on enzymatic activity and aggregation
(Biochimica et Biophysica Acta: Proteins and Proteomics, 2012-10-01) [Artigo]
Hen egg white lysozyme (HEL), an antibacterial enzyme, is a prototype protein for studying the physical and chemical events that underlie the formation of amyloid fibril aggregates. Here, we studied alterations in enzymatic ...