Treinamento aeróbio na aptidão funcional, cognitiva e biomarcadores da doença de Alzheimer em idosos sem demência: um estudo controlado
Data
2013-08-06
Autores
Pereira, Jessica Rodrigues [UNESP]
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Editor
Universidade Estadual Paulista (Unesp)
Resumo
O envelhecimento e/ou fatores a ele associados podem acarretar em alterações no perfil cognitivo que podem estar associadas a processos neurodegenerativos, como, por exemplo, a doença de Alzheimer (DA). A DA é extremamente heterogênea, o que explicaria a dificuldade de tratamento. Por isso, é importante identificar caminhos que, potencialmente, apontem para o seu surgimento, e com isso tornar possível sua prevenção. Sabe-se que biomarcadores como o alelo ε4 da apolipoproteína E (apoE) e o fator neurotrófico derivado do cérebro (BDNF) podem estar atrelados a DA. Por outro lado, o exercício aeróbio parece ser um importante elemento na manutenção do estado cognitivo. Dessa forma, o objetivo do estudo é verificar os efeitos de um programa de treinamento aeróbio nas funções cognitivas, componentes da capacidade funcional e concentrações séricas de BDNF de idosos, pois acredita-se que sujeitos submetidos ao treinamento aeróbio tenham melhor desempenho funcional e cognitivo, bem como um melhor perfil dos biomarcadores de risco da DA. Foi analisada a influência de 16 semanas de treinamento aeróbio nas referidas variáveis. Participaram da amostra 60 idosos, divididos em subgrupos que acordo com a presença ou não do alelo ε4 (grupo treinamento ε4- n=25; grupo treinamento ε4+ n=08; grupo controle ε4- n=18; grupo controle ε4+ n=09) que foram avaliados pelo Escore Clínico de Demência; Questionário de Atividades Instrumentais de Pfeffer; Escala Geriátrica de Depressão; Questionário de Baecke Modificado Para Idosos; Mini Exame do Estado Mental; Montréal Cognitive Assessment; Bateria de testes motores da American Alliance for Health, Physical, Education, Recreation and Dance; teste de sentar-se e levantar-se da cadeira em 30 segundos; Escala do Equilíbrio Funcional de Berg; Timed Up and Go Test; além...
During aging may occur changes on the cognitive profile associated with neurodegenerative processes, for example, Alzheimer's disease (AD). The AD is an extremely heterogeneous, which would explain the difficulty of treatment. So it is important to identify paths for forecasting it, and turns prevention possible. It is known that biomarkers such as apolipoprotein E (apoE) allele ε4 and Brain Derived Neurotrophic Factor (BDNF) may be linked to AD. Aerobic exercise appears to be an important factor in maintaining cognitive state. It is believed that subjects undergoing aerobic training have better cognitive and functional performance, as well as a better risk profile of AD biomarkers. Thus, the aim of the study is to assess the effects of an aerobic training program on cognitive functions, components of functional capacity and serum BDNF, in elderly,. The influence of 16 weeks of aerobic training on these variables was analyzed. A sample of 60 elderly people, assigned into subgroups according to the presence or absence of the allele ε4 (training group ε4-n = 25, group training ε4 + n = 08, control group ε4-n = 18, control group ε4 + n = 09) which were evaluated by the Clinical Dementia Rating; Instrumental Activities Questionnaire Pfeffer, Geriatric Depression Scale, Modified Baecke Questionnaire for Elderly; Mini Mental State Examination; Montréal Cognitive Assessment; American Alliance for Health, Physical, Education , Recreation and Dance battery of motor tests;30-second sit and get up test from the chair,; Berg Balance Scale; Timed Up and Go Test; in addition to laboratory analysis to determine the apoE polymorphism; glucose, triglycerides, LDL, HDL and serum levels of BDNF. The main findings of this study indicate an increase in BDNF... (Complete abstract click electronic access below)
During aging may occur changes on the cognitive profile associated with neurodegenerative processes, for example, Alzheimer's disease (AD). The AD is an extremely heterogeneous, which would explain the difficulty of treatment. So it is important to identify paths for forecasting it, and turns prevention possible. It is known that biomarkers such as apolipoprotein E (apoE) allele ε4 and Brain Derived Neurotrophic Factor (BDNF) may be linked to AD. Aerobic exercise appears to be an important factor in maintaining cognitive state. It is believed that subjects undergoing aerobic training have better cognitive and functional performance, as well as a better risk profile of AD biomarkers. Thus, the aim of the study is to assess the effects of an aerobic training program on cognitive functions, components of functional capacity and serum BDNF, in elderly,. The influence of 16 weeks of aerobic training on these variables was analyzed. A sample of 60 elderly people, assigned into subgroups according to the presence or absence of the allele ε4 (training group ε4-n = 25, group training ε4 + n = 08, control group ε4-n = 18, control group ε4 + n = 09) which were evaluated by the Clinical Dementia Rating; Instrumental Activities Questionnaire Pfeffer, Geriatric Depression Scale, Modified Baecke Questionnaire for Elderly; Mini Mental State Examination; Montréal Cognitive Assessment; American Alliance for Health, Physical, Education , Recreation and Dance battery of motor tests;30-second sit and get up test from the chair,; Berg Balance Scale; Timed Up and Go Test; in addition to laboratory analysis to determine the apoE polymorphism; glucose, triglycerides, LDL, HDL and serum levels of BDNF. The main findings of this study indicate an increase in BDNF... (Complete abstract click electronic access below)
Descrição
Palavras-chave
Aging, Envelhecimento, Capacidade motora, Exercícios físicos para idosos, Alzheimer, Doença de, Cognição
Como citar
PEREIRA, Jessica Rodrigues. Treinamento aeróbio na aptidão funcional, cognitiva e biomarcadores da doença de Alzheimer em idosos sem demência: um estudo controlado. 2013. 59 f. Dissertação - (mestrado) - Universidade Estadual Paulista Júlio de Mesquita Filho, Instituto de Biociências de Rio Claro, 2013.