Avaliação dos efeitos metabólicos da ingestão de quinoa (Chenopodium Quinoa) em um grupo de mulheres pós-menopausa - estudo prospectivo, randomizado, duplo cego
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Data
2011-08-19
Autores
Carvalho, Flávia Giolo de [UNESP]
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Universidade Estadual Paulista (Unesp)
Resumo
Mulheres pós-menopausadas estão mais susceptíveis a problemas de saúde relacionados hipoestrogenismo, o que favorece ao processo de estresse oxidativo, inflamatório e ao desenvolvimento de doenças crônicas. Visto que a inclusão de cereais integrais na alimentação veicula componentes bioativos de efeito antioxidante e hipolipemiante, como as lignanas, o objetivo do presente estudo foi avaliar os efeitos hipolipemiantes, inflamatórios e antioxidantes de lignanas provenientes da ingestão de quinoa (Chenopodium quinoa) em um grupo de mulheres pós-menopausadas. Foi realizado um estudo prospectivo, randomizado, duplo cego e controlado por placebo, no qual participaram 35 mulheres que foram submetidas ao consumo diário de 25 gramas de quinoa em flocos ou placebo, no período de 4 semanas consecutivas. No início e ao final do tratamento, após as quatro semanas, foram realizadas avaliações antropométricas: peso corporal, estatura e circunferência da cintura; e coleta de sangue para a quantificação de glicose, colesterol total, LDL-C, HDL-C, triglicerídeos, marcadores de estresse (GSH e TBARS), Vitamina E, marcadores inflamatórios (IL-6 e TNF-α) e enterolignanas (END e ENL); e urina de 24 horas para quantificação de enterolignanas. Os resultados obtidos foram analisados em dois diferentes estudos os quais foram escritos na forma de artigo científico, sendo que o primeiro artigo abordou o efeito do consumo de quinoa sobre as concentrações de glicose, colesterol total e frações e de marcadores de estresse oxidativo, e o segundo artigo abordou o efeito das enterolignas sobre os marcadores inflamatórios em um grupo de mulheres pós-menopausadas. Ao comparar as dosagens no início e ao final do experimento, o presente estudo mostrou um possível efeito benéfico proveniente da ingestão do cereal quinoa, pois foram constatadas reduções significativas nas concentrações...
Postmenopausal women are more susceptible to health problems related to declining estrogen concentrations, which favor the oxidative stress and inflammatory process and the development of chronic diseases. Since daily consumption of grains involves bioactive components with an antioxidant and hypolipidemic effects, like lignans, the aim of the present study was to investigate the effect of quinoa consumption on the concentrations of glucose, total cholesterol and fractions, oxidative stress and inflammatory markers in a group of postmenopausal women. A prospective, randomized, double-blind and placebo-controlled study has been conducted on 35 women who had to consume 25 grams/day of quinoa flakes or placebo, over a period of 4 consecutive weeks. At the beginning and at the end of the intervention, after four weeks, anthropometric assessment was performed by body weight, height and abdominal circumference; and blood was collected for the determination of glucose, total cholesterol and fractions, oxidative stress and inflammatory markers, vitamin E and enterolignans, and 24-h urine was obtained for the determination of enterolignans. The results were analyzed in two different studies which were written in the form of a scientific paper, the first one emphasizes the effect of quinoa intake on consumption on the concentrations of glucose, total cholesterol and fractions, oxidative stress markers and in the second paper investigated the effect of enterolignans on inflammatory markers in a group of postmenopausal women. Comparing the beginning and the end of the intervention, the present study showed a possible beneficial effect by quinoa intake, because significant reductions were observed in serum triglycerides, TBARS and vitamin E concentrations, and an increase in enterolignan urinary excretion in the groups that consumed quinoa and placebo. A significant reduction of total cholesterol... (Complete abstract click electronic access below)
Postmenopausal women are more susceptible to health problems related to declining estrogen concentrations, which favor the oxidative stress and inflammatory process and the development of chronic diseases. Since daily consumption of grains involves bioactive components with an antioxidant and hypolipidemic effects, like lignans, the aim of the present study was to investigate the effect of quinoa consumption on the concentrations of glucose, total cholesterol and fractions, oxidative stress and inflammatory markers in a group of postmenopausal women. A prospective, randomized, double-blind and placebo-controlled study has been conducted on 35 women who had to consume 25 grams/day of quinoa flakes or placebo, over a period of 4 consecutive weeks. At the beginning and at the end of the intervention, after four weeks, anthropometric assessment was performed by body weight, height and abdominal circumference; and blood was collected for the determination of glucose, total cholesterol and fractions, oxidative stress and inflammatory markers, vitamin E and enterolignans, and 24-h urine was obtained for the determination of enterolignans. The results were analyzed in two different studies which were written in the form of a scientific paper, the first one emphasizes the effect of quinoa intake on consumption on the concentrations of glucose, total cholesterol and fractions, oxidative stress markers and in the second paper investigated the effect of enterolignans on inflammatory markers in a group of postmenopausal women. Comparing the beginning and the end of the intervention, the present study showed a possible beneficial effect by quinoa intake, because significant reductions were observed in serum triglycerides, TBARS and vitamin E concentrations, and an increase in enterolignan urinary excretion in the groups that consumed quinoa and placebo. A significant reduction of total cholesterol... (Complete abstract click electronic access below)
Descrição
Palavras-chave
Quinoa, Pós-menopausa, Inflamação, Enterolignans, Cholesterolemia, Oxidative stress, Inflammatory markers, Post menopause
Como citar
CARVALHO, Flávia Giolo de. Avaliação dos efeitos metabólicos da ingestão de quinoa (Chenopodium Quinoa) em um grupo de mulheres pós-menopausa - estudo prospectivo, randomizado, duplo cego. 2011. 78 f. Dissertação (mestrado) - Universidade Estadual Paulista, Faculdade de Ciências Farmacêuticas, 2011.