Avaliação de dentifrício com concentração reduzida de fluoreto associado ao glicerofosfato de cálcio na desmineralização do esmalte dentário in situ
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2011-02-22
Autores
Amaral, Jackeline Gallo do [UNESP]
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Universidade Estadual Paulista (Unesp)
Resumo
O uso do fluoreto tem sido considerado um importante fator na redução da incidência da cárie dentária, porém tem-se verificado um aumento da fluorose dentária quando associado ao uso deste elemento. O objetivo deste estudo foi verificar o efeito de um dentifrício com concentração reduzida de fluoreto suplementado com glicerofosfato de cálcio (GPCa) em inibir o processo de desmineralização e sobre a placa dental formada in situ. Voluntários (n=10) participaram de 4 fases experimentais de 7 dias de duração cada, em cada fase utilizaram um dispositivo palatino contendo 4 blocos de esmalte dental bovino. O desafio cariogênico foi realizado por meio de solução de sacarose 30%, 6 vezes ao dia. Os dentifrícios utilizados neste estudo foram: placebo, 500 μg F/g, 500 μg F/g com 0,25% de GPCa e 1100 μg F/g. Decorrido o período experimental, a placa dental foi coletada, processada, a concentração iônica (fluoreto, cálcio e fosfato) e de polissacarídeos extracelulares (PEC) determinadas. Analisou-se a dureza de superfície inicial e final e em secção longitudinal. Determinou-se a concentração de fluoreto, cálcio e fosfato no esmalte. O uso de dentifrícios contendo 1100 μg F/g e 500 μg F/g com 0,25% de GPCa levou a concentrações semelhantes de fluoreto, cálcio e fosfato na placa, as quais foram maiores que as obtidas após o uso dos demais dentifrícios. A concentração de PEC e a perda mineral foram menores nos dentifrícios 1100 μg F/g e 500 μg F/g com 0,25% de GPCa, seguido pelo 500 μg F/g e placebo, o qual apresentou os menores valores. As concentrações de fluoreto, cálcio e fosfato no esmalte foram menores no grupo placebo, sendo os maiores valores encontrados nos grupos 500 μg F/g com 0,25% de GPCa e 1100 μg F/g (p<0,05). De acordo com os resultados o dentifrício com baixa concentração associado ao GPCa, apresentou resultado semelhante ao...
The use of fluoride has been considered as an important factor for decrease in the incidence of dental caries, however dental fluorosis increase associated with the use of this element. This in situ study aims to evaluate the effect of low fluoride concentration dentifrices supplemented with calcium glycerophosphate (CaGP) in inhibiting the demineralization process and on the dental plaque formed in situ. Ten volunteers wore palatal devices containing 4 blocks of bovine dental enamel over 3 periods of 7 days each. In each phase, treatment was accomplished with a nonfluoride dentifrice (placebo), a 500 μg F/g, a 500 μg F/g with 0.25% CaGP and a 1,100 μg F/g dentifrice, under cariogenic challenge with 30% sucrose solution 6 times a day. After that, the dental plaque was collected and processed, and the ionic (fluoride, calcium, and phosphate) and insoluble extracellular polysaccharide (EPS) concentrations were appraised. To evaluate mineral loss, we determined both the initial and final surface hardness and cross-sectional hardness (ΔKHN). The fluoride, calcium, and phosphate concentration in the enamel were determined. The use of dentifrices containing 1100 μg F/g and 500 μg F/g with 0.25% CaGP led to similar concentrations of fluoride, calcium and phosphate in dental plaque, but higher than those obtained after the use of the placebo and 500 μg F/g dentifrices . The concentration of EPS and mineral loss was lower in 500 μg F/g with 0.25% of CaGP e 1,100 μg F/g. The concentration of fluoride, calcium, and phosphate in enamel was higher in groups 500 μg F/g with 0.25% of CaGP e 1,100 μg F/g (p <0.05). It was concluded that the low fluoride concentration dentifrice with 0.25% CaGP, showed similar efficacy to the positive control (1,100 μg F / g) in demineralization in situ, could be an alternative to improve the risk-benefit relationship between fluorosis and dental caries
The use of fluoride has been considered as an important factor for decrease in the incidence of dental caries, however dental fluorosis increase associated with the use of this element. This in situ study aims to evaluate the effect of low fluoride concentration dentifrices supplemented with calcium glycerophosphate (CaGP) in inhibiting the demineralization process and on the dental plaque formed in situ. Ten volunteers wore palatal devices containing 4 blocks of bovine dental enamel over 3 periods of 7 days each. In each phase, treatment was accomplished with a nonfluoride dentifrice (placebo), a 500 μg F/g, a 500 μg F/g with 0.25% CaGP and a 1,100 μg F/g dentifrice, under cariogenic challenge with 30% sucrose solution 6 times a day. After that, the dental plaque was collected and processed, and the ionic (fluoride, calcium, and phosphate) and insoluble extracellular polysaccharide (EPS) concentrations were appraised. To evaluate mineral loss, we determined both the initial and final surface hardness and cross-sectional hardness (ΔKHN). The fluoride, calcium, and phosphate concentration in the enamel were determined. The use of dentifrices containing 1100 μg F/g and 500 μg F/g with 0.25% CaGP led to similar concentrations of fluoride, calcium and phosphate in dental plaque, but higher than those obtained after the use of the placebo and 500 μg F/g dentifrices . The concentration of EPS and mineral loss was lower in 500 μg F/g with 0.25% of CaGP e 1,100 μg F/g. The concentration of fluoride, calcium, and phosphate in enamel was higher in groups 500 μg F/g with 0.25% of CaGP e 1,100 μg F/g (p <0.05). It was concluded that the low fluoride concentration dentifrice with 0.25% CaGP, showed similar efficacy to the positive control (1,100 μg F / g) in demineralization in situ, could be an alternative to improve the risk-benefit relationship between fluorosis and dental caries
Descrição
Palavras-chave
Dentifrícios, Fluoretos, Placas dentarias, Glicerofosfatos, Desmineralização do dente, Placa dentária, Dentifrices, Fluorides, Glycerophosphates, Tooth demineralization, Dental plaque
Como citar
AMARAL, Jackeline Gallo do. Avaliação de dentifrício com concentração reduzida de fluoreto associado ao glicerofosfato de cálcio na desmineralização do esmalte dentário in situ. 2011. 68 f. Dissertação (mestrado) - Universidade Estadual Paulista, Faculdade de Odontologia de Araçatuba, 2011.