Avaliação clínica-epidemiológica e laboratorial do eixo hipotálamo-hipósise-goodal de pacientes com obesidade classe III
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Data
2008-08-08
Autores
Souza, Francisco de Assis Costa [UNESP]
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Editor
Universidade Estadual Paulista (Unesp)
Resumo
A obesidade classe III ou mórbida determina um risco significativamente aumentado para complicações metabólicas. Também são referenciadas alterações ginecológicas, como as irregularidades menstruais, o hirsutismo e as alterações hormonais. Avaliação dos aspectos clínicos-epidemiológicoslaboratoriais de pacientes com obesidade classe III, portadoras de distúrbios metabólicos e hormonais. Foram analisadas 58 mulheres com obesidade classe III ou mórbida e divididas em 2 grupos de estudo; sendo um grupo com mulheres obesas grau III sem disfunção menstrual ou hirsutismo, (Grupo C) e outro grupo com mulheres obesas grau III apresentando disfunção menstrual associada ou não a hirsutismo (Grupo E). Foram avaliadas a idade, cor, paridade, estado civil, profissão, nível sócio-econômico, escolaridade, idade da menarca, peso corporal, estatura, índice de massa corpórea, presença de hirsutismo (Índice de Ferriman e Gallwey), medida da circunferência abdominal (CA), medida da circunferência do quadril (CQ), relação cintura-quadril (RCQ), ciclo menstrual, medida da pressão arterial, presença da acantose nigricans, avaliação da resistência a insulina, glicemia de jejum (GJ), colesterol total (CT), HDL-C, LDL-C, triglicerídeos (TG), hormônio tireo-estimulante (TSH), T4 livre, hormônio luteinizante (LH), o hormônio folículo-estimulante (FSH), prolactina (PRL), Testosterona total, sulfato de dehidroepiandrosteron (DHEA-S), a insulina e o HOMA test. Os aspectos clínicos-epidemiológicos não apresentaram diferenças estatísticas. Os parâmetros clínicos e laboratoriais não apresentaram alterações estatisticamente significativas; entretanto, os valores do HOMA test para o grupo E foram significantemente maiores que os pacientes do grupo C. Em mulheres obesas classe III a presença da resistência...
Class-III or morbid obesity determines significantly increased risk for metabolic complications. Gynecologic alterations, such menstrual irregularity, hirsutism and hormonal alterations are also reported. To evaluate the clinical, epidemiological and laboratory aspects of patients with class-III obesity showing metabolic and hormonal disorders. Fiftyeight women with class-III or morbid obesity were evaluated. They were divided into 2 groups: one group comprising grade-III obese women without menstrual dysfunctions or hirsutism (Group C), and another with grade-III obese women showing menstrual dysfunction associated with hirsutism or not (Group E). The following aspects were evaluated age, color, parity, marital status, profession, socioeconomic level, education, age at menarche, body weight, height, body mass index, presence of hirsutism (Ferriman and Gallwey Index), abdominal circumference measurement (AC), hips circumference measurement (HC), waist-to-hip ratio (WHR), menstrual cycle, blood pressure, presence of acanthosis nigricans, evaluation of insulin resistance, fasting glycemia (FG), total cholesterol (TC), HDL-C, LDL-C, triglycerides (TG), thyroidstimulating hormone (TSH), free T4, luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), total testosterone, dehydroepiandrosterone sulfate (DHEA-S), insulin and the HOMA test. The clinical and epidemiological aspects did not present statistical differences. The clinical and laboratory parameters did not show statistically significant alterations; however, the HOMA test values for group E were significantly higher than those for patients in group C. In class-III obese women, the presence of insulin resistance can cause menstrual dysfunctions, such as amenorrhea or oligomenorrhea even in the absence of hyperandrogenism, thus suggesting... (Complete abstract click electronic access below)
Class-III or morbid obesity determines significantly increased risk for metabolic complications. Gynecologic alterations, such menstrual irregularity, hirsutism and hormonal alterations are also reported. To evaluate the clinical, epidemiological and laboratory aspects of patients with class-III obesity showing metabolic and hormonal disorders. Fiftyeight women with class-III or morbid obesity were evaluated. They were divided into 2 groups: one group comprising grade-III obese women without menstrual dysfunctions or hirsutism (Group C), and another with grade-III obese women showing menstrual dysfunction associated with hirsutism or not (Group E). The following aspects were evaluated age, color, parity, marital status, profession, socioeconomic level, education, age at menarche, body weight, height, body mass index, presence of hirsutism (Ferriman and Gallwey Index), abdominal circumference measurement (AC), hips circumference measurement (HC), waist-to-hip ratio (WHR), menstrual cycle, blood pressure, presence of acanthosis nigricans, evaluation of insulin resistance, fasting glycemia (FG), total cholesterol (TC), HDL-C, LDL-C, triglycerides (TG), thyroidstimulating hormone (TSH), free T4, luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), total testosterone, dehydroepiandrosterone sulfate (DHEA-S), insulin and the HOMA test. The clinical and epidemiological aspects did not present statistical differences. The clinical and laboratory parameters did not show statistically significant alterations; however, the HOMA test values for group E were significantly higher than those for patients in group C. In class-III obese women, the presence of insulin resistance can cause menstrual dysfunctions, such as amenorrhea or oligomenorrhea even in the absence of hyperandrogenism, thus suggesting... (Complete abstract click electronic access below)
Descrição
Palavras-chave
Obesidade mórbida, Resistência à insulina, Distúrbios mentruais, Morbid obesity, Hyperandrogenism
Como citar
SOUZA, Francisco de Assis Costa. Avaliação clínica-epidemiológica e laboratorial do eixo hipotálamo-hipósise-goodal de pacientes com obesidade classe III. 2008. 91 f. Dissertação (mestrado) - Universidade Estadual Paulista, Faculdade de Medicina de Botucatu, 2008.