Synthesis and antitubercular evaluation of new 1,2,3-triazole derivatives of carbohydrates

Santos, Juliana Alves dos; Corrales, Roberta Cristina Novaes Reis; Pavan, Fernando Rogério [UNESP]; Leite, Clarice Queico Fujimura [UNESP]; Dias, Rafael Mafra de Paula; Silva, Adilson David da

Synthesis and antitubercular evaluation of new 1,2,3-triazole derivatives of carbohydrates

Arquivos

ISSN2028-3997-2012-01-06-281-288.pdf (329.99 KB)

Data

2012

Autores

Santos, Juliana Alves dos

Corrales, Roberta Cristina Novaes Reis

Pavan, Fernando Rogério

Leite, Clarice Queico Fujimura

Dias, Rafael Mafra de Paula

Silva, Adilson David da

Tipo

Artigo

Direito de acesso

Acesso aberto

Resumo

We reported in this work the preparation of novel 1,4-disubstituted-1,2,3-triazoles derivatives from Dglucose and D-fructose and their in vitro antibacterial activity against Mycobacterium tuberculosis were evaluated. The chemical synthesis was performed based on the 1,3-dipolar cycloaddition reaction, and antimicrobial activity was determined based on Resazurin Microtiter Assay against Mycobacterium. None of the triazole glycoconjugates tested showed activity against these microorganisms.