Phenotypic alterations of neuropeptide Y and calcitonin gene-related peptide-containing neurons innervating the rat temporomandibular joint during carrageenan-induced arthritis

dc.contributor.authorDamico, J. P.
dc.contributor.authorErvolino, Edilson [UNESP]
dc.contributor.authorTorres, K. R.
dc.contributor.authorBatagello, D. S.
dc.contributor.authorCruz-Rizzolo, R. J. [UNESP]
dc.contributor.authorCasatti, Cláudio Aparecido [UNESP]
dc.contributor.authorBauer, J. A.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2013-09-30T18:29:20Z
dc.date.accessioned2014-05-20T13:43:06Z
dc.date.available2013-09-30T18:29:20Z
dc.date.available2014-05-20T13:43:06Z
dc.date.issued2012-01-01
dc.description.abstractThe aim of this study was to identify immunoreactive neuropeptide Y (NPY) and calcitonin gene-related peptide (CGRP) neurons in the autonomic and sensory ganglia, specifically neurons that innervate the rat temporomandibular joint (TMJ). A possible variation between the percentages of these neurons in acute and chronic phases of carrageenan-induced arthritis was examined. Retrograde neuronal tracing was combined with indirect immunofluorescence to identify NPY-immuno-reactive (NPY-IR) and CGRP-immunoreactive (CGRP-IR) neurons that send nerve fibers to the normal and arthritic temporomandibular joint. In normal joints, NPY-IR neurons constitute 78 +/- 3%, 77 +/- 6% and 10 +/- 4% of double-labeled nucleated neuronal profile originated from the superior cervical, stellate and otic ganglia, respectively. These percentages in the sympathetic ganglia were significantly decreased in acute (58 +/- 2% for superior cervical ganglion and 58 +/- 8% for stellate ganglion) and chronic (60 +/- 2% for superior cervical ganglion and 59 +/- 15% for stellate ganglion) phases of arthritis, while in the otic ganglion these percentages were significantly increased to 19 +/- 5% and 13 +/- 3%, respectively. In the trigeminal ganglion, CGRP-IR neurons innervating the joint significantly increased from 31 +/- 3% in normal animals to 54 +/- 2% and 49 +/- 3% in the acute and chronic phases of arthritis, respectively. It can be concluded that NPY neurons that send nerve fibers to the rat temporomandibular joint are located mainly in the superior cervical, stellate and otic ganglia. Acute and chronic phases of carrageenan-induced arthritis lead to an increase in the percentage of NPY-IR parasympathetic and CGRP-IR sensory neurons and to a decrease in the percentage of NPY-IR sympathetic neurons related to TMJ innervation.en
dc.description.affiliationUniv São Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, Sch Dent Aracatuba, Dept Basic Sci, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Inst Biomed Sci, Dept Anat, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Sch Dent Aracatuba, Dept Basic Sci, São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 98/16464-4
dc.description.sponsorshipIdFAPESP: 99/12629-1
dc.format.extent191-200
dc.identifierhttp://dx.doi.org/10.4081/ejh.2012.e31
dc.identifier.citationEuropean Journal of Histochemistry. Pavia: Pagepress Publ, v. 56, n. 3, p. 191-200, 2012.
dc.identifier.doi10.4081/ejh.2012.e31
dc.identifier.fileWOS000314399500007.pdf
dc.identifier.issn1121-760X
dc.identifier.lattes4408095517346846
dc.identifier.lattes8487462626931877
dc.identifier.orcid0000-0003-4859-0583
dc.identifier.orcid0000-0001-5650-7343
dc.identifier.urihttp://hdl.handle.net/11449/15002
dc.identifier.wosWOS:000314399500007
dc.language.isoeng
dc.publisherPagepress Publ
dc.relation.ispartofEuropean Journal of Histochemistry
dc.relation.ispartofjcr2.217
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjecttrigeminal ganglionen
dc.subjectotic ganglionen
dc.subjectsuperior cervical ganglionen
dc.subjectarthritisen
dc.subjecttemporomandibular jointen
dc.titlePhenotypic alterations of neuropeptide Y and calcitonin gene-related peptide-containing neurons innervating the rat temporomandibular joint during carrageenan-induced arthritisen
dc.typeArtigo
dcterms.licensehttp://www.pagepress.org/open_access.html
dcterms.rightsHolderPagepress Publ
unesp.author.lattes4408095517346846[2]
unesp.author.lattes8487462626931877[6]
unesp.author.orcid0000-0003-4859-0583[2]
unesp.author.orcid0000-0002-4436-0185[4]
unesp.author.orcid0000-0002-0920-0581[5]
unesp.author.orcid0000-0001-5650-7343[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt

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