Role of sex hormones in hypercapnia-induced activation of the locus coeruleus in female and male rats

dc.contributor.authorde Carvalho, D. [UNESP]
dc.contributor.authorMarques, D. A. [UNESP]
dc.contributor.authorBernuci, M. P.
dc.contributor.authorLeite, C. M.
dc.contributor.authorAraújo-Lopes, R.
dc.contributor.authorAnselmo-Franci, J.
dc.contributor.authorBícego, K. C. [UNESP]
dc.contributor.authorSzawka, R. E.
dc.contributor.authorGargaglioni, L. H. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-12-11T16:59:23Z
dc.date.available2018-12-11T16:59:23Z
dc.date.issued2016-01-28
dc.description.abstractThe locus coeruleus (LC) has been suggested as a CO2 chemoreceptor site in mammals. Most of the studies involving the role of the LC in hypercapnic ventilatory responses have been performed in males. Since ovarian steroids modulate the activity of LC neurons and females have a different respiratory response to CO2 than males, we evaluated the activity of LC noradrenergic neurons during normocapnia and hypercapnia in female and male rats with distinct sex hormone levels. Ovariectomized (OVX), estradiol (E2)-treated ovariectomized (OVX+E2) and female rats on the diestrous day of the estrous cycle were evaluated. Concurrently, males were investigated as gonad-intact, orchidectomized (ORX), testosterone (T)-treated ORX (ORX+T), and E2-treated ORX (ORX+E2). Activation of LC neurons was determined by double-label immunohistochemistry to c-Fos and tyrosine hydroxylase (TH). Hypercapnia induced by 7% CO2 increased the number of c-Fos/TH-immunoreactive (ir) neurons in the LC of all groups when compared to air exposure. Hypercapnia-induced c-Fos expression did not differ between diestrous females and intact male rats. In the OVX+E2 group, there was attenuation in the c-Fos expression during normocapnia compared with OVX rats, but CO2 responsiveness was not altered. Moreover, in ORX rats, neither T nor E2 treatments changed c-Fos expression in LC noradrenergic neurons. Thus, in female rats, E2 reduces activation of LC noradrenergic neurons, whereas in males, sex hormones do not influence the LC activity.en
dc.description.affiliationDepartment of Animal Morphology and Physiology Sao Paulo State University - UNESP FCAV
dc.description.affiliationDepartment of Physiology and Biophysics Institute of Biological Sciences Federal University of Minas Gerais - UFMG
dc.description.affiliationStomatology Morphology and Physiology FORP-University of Sao Paulo
dc.description.affiliationUnespDepartment of Animal Morphology and Physiology Sao Paulo State University - UNESP FCAV
dc.format.extent36-45
dc.identifierhttp://dx.doi.org/10.1016/j.neuroscience.2015.11.026
dc.identifier.citationNeuroscience, v. 313, p. 36-45.
dc.identifier.doi10.1016/j.neuroscience.2015.11.026
dc.identifier.file2-s2.0-84948844920.pdf
dc.identifier.issn1873-7544
dc.identifier.issn0306-4522
dc.identifier.scopus2-s2.0-84948844920
dc.identifier.urihttp://hdl.handle.net/11449/172254
dc.language.isoeng
dc.relation.ispartofNeuroscience
dc.relation.ispartofsjr1,602
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectC-Fos
dc.subjectChemosensitivity
dc.subjectEstradiol
dc.subjectNoradrenaline
dc.subjectSex steroids
dc.titleRole of sex hormones in hypercapnia-induced activation of the locus coeruleus in female and male ratsen
dc.typeArtigo
unesp.author.orcid0000-0003-4097-5286[9]

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