Circulating levels of vascular endothelial growth factor in patients with Alzheimer's disease: A case-control study

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dc.contributor.authorSilva, Thays Martins Vital da [UNESP]
dc.contributor.authorStein, Angelica Miki [UNESP]
dc.contributor.authorCoelho, Flávia Gomes de Melo [UNESP]
dc.contributor.authorRueda, Andre Veloso
dc.contributor.authorCamarini, Rosana
dc.contributor.authorGalduróz, Ruth Ferreira [UNESP]
dc.contributor.institutionInstituto Federal do Triangulo Mineiro
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionFederal University of Technology – Paraná (UTFPR)
dc.contributor.institutionMidwestern Parana State University (UNICENTRO)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal do ABC (UFABC)
dc.date.accessioned2023-07-29T13:24:58Z
dc.date.available2023-07-29T13:24:58Z
dc.date.issued2023-02-02
dc.description.abstractBackground: Vascular endothelial growth factor (VEGF) and platelets seem to reflect the Alzheimer's disease (AD) associated either with vascular impairment or disease. This study aimed to compare the circulating levels of VEGF and platelets between AD patients and healthy older adults. Methods: Seventy-two older adults, divided in 40 older adults (Clinical Dementia Rating Scale – CDR = 0); and 32 Alzheimer's disease patients (clinically diagnosed – CRD = 1) participated in the present study. The groups were paired by sex, age, comorbidities and educational level. The primary outcomes included circulating plasma VEGF and platelet levels obtained by blood collection. Results: The VEGF levels were significantly different between the groups (p = 0.03), with having a large effect size ( η2 =18.15), in which the AD patients presented lower levels compared to healthy older adults. For platelets, the comparison showed a tendency to difference (p = 0.06), with a large effect size (η2 =12.95) between the groups. Conclusion: The VEGF levels and the platelet numbers were reduced in AD patients, suggesting that angiogenic factors could be modified due to AD.en
dc.description.affiliationInstituto Federal do Triangulo Mineiro, Campus Patos de Minas
dc.description.affiliationInstitute of Biosciences UNESP (Universidade Estadual Paulista) Physical Activity and Aging Lab (LAFE), Campus Rio Claro
dc.description.affiliationUTFPR Federal University of Technology – Paraná (UTFPR), Campus Curitiba
dc.description.affiliationDepartment of Physical Education Midwestern Parana State University (UNICENTRO)
dc.description.affiliationDepartamento de Farmacologia Instituto de Ciências Biomédicas Universidade de São Paulo, Campus São Paulo
dc.description.affiliationCenter of Mathematics Computing and Cognition University Federal of ABC (UFABC), Campus São Bernardo
dc.description.affiliationUnespInstitute of Biosciences UNESP (Universidade Estadual Paulista) Physical Activity and Aging Lab (LAFE), Campus Rio Claro
dc.description.sponsorshipJohns Hopkins University
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: #2012/21286-7
dc.description.sponsorshipIdCNPq: 153874/2018-0
dc.identifierhttp://dx.doi.org/10.1016/j.bbr.2022.114126
dc.identifier.citationBehavioural Brain Research, v. 437.
dc.identifier.doi10.1016/j.bbr.2022.114126
dc.identifier.issn1872-7549
dc.identifier.issn0166-4328
dc.identifier.scopus2-s2.0-85140080610
dc.identifier.urihttp://hdl.handle.net/11449/247754
dc.language.isoeng
dc.relation.ispartofBehavioural Brain Research
dc.sourceScopus
dc.subjectAging
dc.subjectBiomarker
dc.subjectDementia
dc.titleCirculating levels of vascular endothelial growth factor in patients with Alzheimer's disease: A case-control studyen
dc.typeArtigo

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