DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status
Carregando...
Arquivos
Data
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Biomed Central Ltd
Tipo
Artigo
Direito de acesso
Acesso aberto
Resumo
Background: Jorge Lobo's disease, also known as lacaziosis, is a cutaneous-subcutaneous mycosis with chronic evolution. It is caused by the fungus Lacazia loboi. Herein we report a study that relates the genotoxicity caused by L. loboi in isogenic mice with nutritional status, through a normal or restricted diet.Methods: DNA damage was assessed in the peripheral blood by the comet assay (tail intensity).Results: The results for leukocytes showed increases in the mean tail intensity in mice under dietary restriction, in infected mice under dietary restriction and in infected mice ingesting a normal diet.Conclusion: These results indicate that dietary restriction and L. loboi infection may increase DNA damage levels in mice, as detected by the comet assay.
Descrição
Palavras-chave
Jorge Lobo'disease, Lacazia loboi, Malnutrition, Mice, Genotoxicity, Comet assay
Idioma
Inglês
Citação
Journal Of Venomous Animals And Toxins Including Tropical Diseases, London, v. 21, 5 p., 2015.
