Effect of systemic antibiotic and probiotic therapies as adjuvant treatments of subgingival instrumentation for periodontitis: a randomized controlled clinical study

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dc.contributor.authorRamos, Tatiane Caroline de Souza [UNESP]
dc.contributor.authorBoas, Mariéllen Longo Vilas [UNESP]
dc.contributor.authorNunes, Camilla Magnoni Moretto [UNESP]
dc.contributor.authorFerreira, Camila Lopes [UNESP]
dc.contributor.authorPannuti, Cláudio Mendes
dc.contributor.authorSantamaria, Mauro Pedrine [UNESP]
dc.contributor.authorJardini, Maria Aparecida Neves [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2022-05-01T15:46:18Z
dc.date.available2022-05-01T15:46:18Z
dc.date.issued2022-01-01
dc.description.abstractOBJECTIVE: This study assessed the efficacy of two adjunct therapies (antibiotic and probiotic) for periodontal treatment based on clinical and immunological parameters in patients with Stage II and III Grade B periodontitis. METHODOLOGY: 45 patients were randomly allocated into three groups: control group (CG); antibiotic group (GAtb), in which 500 mg amoxicillin + 400 mg metronidazole were used; and probiotic group (GProb), for which Lactobacillus reuteri was used. Patients received medications after undergoing periodontal debridement. Clinical and immunological parameters were assessed at baseline, 30 days, and 90 days. RESULTS: All therapies reduced bleeding on probing (BoP) in the evaluated periods, and the GAtb had a greater reduction at 90 days (p=0.03). The GProb group showed better results for plaque index (PI) and gingival recession (GR) compared to the GAtb at 90 days (p=0.0014; p=0.006). The area of inflammation (PISA Index) significantly decreased in all therapies in the evaluated periods. Therapies had no significant differences regarding moderate pockets. The GAtb had a greater reduction in probing depth (PD) for deep pockets (p=0.03) at 90 days and in the number of deep pocket sites at 30 days (p=0.04). The occurrence of adverse effects was commonly reported in the GAtb as a percentage per patient. The GAtb had a significant reduction in the concentration of interleukins IL-1β and IL-8 and an increase in IL-10 and TNF-α. The CG had a reduction in IL-6 and IL-1 β, whereas in the GProb there was no difference. CONCLUSION: After three months, none of the adjuvant therapies provided any additional benefit for subgingival instrumentation.en
dc.description.affiliationUniversidade Estadual Paulista (UNESP) Faculdade de Odontologia Programa de Biopatologia Bucal Área de Periodontia
dc.description.affiliationUniversidade de São Paulo (USP) Faculdade de Odontologia Divisão de Periodontia Departamento de Estomatologia
dc.description.affiliationUniversidade Estadual Paulista (UNESP) Instituto de Ciências e Tecnologia Departamento de Diagnóstico e Cirurgia Área de Periodontia
dc.description.affiliationUnespUniversidade Estadual Paulista (UNESP) Faculdade de Odontologia Programa de Biopatologia Bucal Área de Periodontia
dc.description.affiliationUnespUniversidade Estadual Paulista (UNESP) Instituto de Ciências e Tecnologia Departamento de Diagnóstico e Cirurgia Área de Periodontia
dc.format.extente20210583
dc.identifierhttp://dx.doi.org/10.1590/1678-7757-2021-0583
dc.identifier.citationJournal of applied oral science : revista FOB, v. 30, p. e20210583-.
dc.identifier.doi10.1590/1678-7757-2021-0583
dc.identifier.issn1678-7765
dc.identifier.scopus2-s2.0-85126907410
dc.identifier.urihttp://hdl.handle.net/11449/234305
dc.language.isoeng
dc.relation.ispartofJournal of applied oral science : revista FOB
dc.sourceScopus
dc.titleEffect of systemic antibiotic and probiotic therapies as adjuvant treatments of subgingival instrumentation for periodontitis: a randomized controlled clinical studyen
dc.typeArtigo
unesp.author.orcid0000-0003-1469-0930[1]
unesp.author.orcid0000-0003-0487-4728[2]
unesp.author.orcid0000-0002-5399-0314[3]
unesp.author.orcid0000-0002-2320-6525[4]
unesp.author.orcid0000-0003-4181-3975[5]
unesp.author.orcid0000-0001-9468-0729[6]
unesp.author.orcid0000-0003-3229-8019[7]

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Artigos - Diagnóstico e Cirurgia - ICT