Estudo da ação da dexametasona na regeneração da nadadeira caudal de Cyprinus carpio (Carpa) (Linnaeus, 1758)

dc.contributor.authorOchandio, B. S. [UNESP]
dc.contributor.authorBechara, I. J.
dc.contributor.authorParise-Maltempi, P. P. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2018-12-11T16:38:44Z
dc.date.available2018-12-11T16:38:44Z
dc.date.issued2015-01-01
dc.description.abstractStudies have demonstrated that the prolonged use of corticoids can delay the healing process, affecting re-epithelialization, neovascularization and collagen synthesis. As the fins of teleost fish contain a large amount of collagen, the aim of the present study was to investigate the effect of dexamethasone (anti-inflammatory and glucocorticoid steroid widely used in the treatment of rheumatic diseases) during the regeneration process in the caudal fin of specimens of carp (Cyprinus carpio). For such, two glass aquaria were used – one for a group of fish treated with dexamethasone (Henrifarma) in a 20 mg/L concentration and the other for the control group. The caudal fins were amputated transversally and fish remained in their respective aquaria until regeneration occurred. Samples of regenerating fins were collected on days 1, 2, 4, 6, 8 and 10 after amputation. The fins in the control group regenerated normally and grew within the expected in time course. The fins in the group treated with dexamethasone were significantly smaller in comparison to the control group at every evaluation time. Thus, it was possible to verify that, at this concentration of dexamethasone, the regeneration of the caudal fins was delayed, but not completely inhibited. The results show that the caudal fin is a good model for histological studies on regeneration and the action of drug toxicity, but it’s also of great importance the interaction with further studies for a better knowledge and understanding of all the changes in all the phases.en
dc.description.affiliationDepartamento de Biologia, Instituto de Biociências, Universidade Estadual Paulista ‘Júlio de Mesquita Filho’ – UNESP, Av. 24A, 1515
dc.description.affiliationLaboratório de Histofisiologia e Histopatologia Experimental em Ectotérmicos, Departamento de Histologia e Embriologia, Instituto de Biologia, Universidade Estadual de Campinas – UNICAMP, CP 6109
dc.description.affiliationUnespDepartamento de Biologia, Instituto de Biociências, Universidade Estadual Paulista ‘Júlio de Mesquita Filho’ – UNESP, Av. 24A, 1515
dc.format.extent442-450
dc.identifierhttp://dx.doi.org/10.1590/1519-6984.16813
dc.identifier.citationBrazilian Journal of Biology, v. 75, n. 2, p. 442-450, 2015.
dc.identifier.doi10.1590/1519-6984.16813
dc.identifier.fileS1519-69842015000200027.pdf
dc.identifier.issn1678-4375
dc.identifier.issn1519-6984
dc.identifier.scieloS1519-69842015000200027
dc.identifier.scopus2-s2.0-84936753380
dc.identifier.urihttp://hdl.handle.net/11449/167888
dc.language.isoeng
dc.relation.ispartofBrazilian Journal of Biology
dc.relation.ispartofsjr0,523
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectCaudal fin
dc.subjectCollagen
dc.subjectDexamethasone
dc.subjectFish
dc.subjectTissue regeneration
dc.titleEstudo da ação da dexametasona na regeneração da nadadeira caudal de Cyprinus carpio (Carpa) (Linnaeus, 1758)pt
dc.title.alternativeDexamethasone action on caudal fin regeneration of carp Cyprinus carpio (Linnaeus, 1758)en
dc.typeArtigo

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