EFEIFOS DO SULFATE DE MAGNESIO NA HEMODINAMICA CARDIOVASCULAR DE CAES ANESTESIADOS COM PENTOBARBITAL SODICO

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dc.contributor.authorGanem, Eliana Marisa [UNESP]
dc.contributor.authorCastiglia, Yara Marcondes Machado [UNESP]
dc.contributor.authorVianna, Pedro Thadeu Galvão [UNESP]
dc.contributor.authorBraz, José Reinaldo Cerqueira [UNESP]
dc.contributor.authorMódolo, Norma Sueli Pinheiro [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:18:03Z
dc.date.available2014-05-27T11:18:03Z
dc.date.issued1996-01-01
dc.description.abstractBackground and Objectives - A controversy exists in the literature regarding the effects of the acute administration of magnesium on the cardiovascular system of animals and humans. The purpose of this study was to evaluate the effects of hypermagnesemia on the cardiovascular hemodynamics of dogs. Methods - Sixteen mongrel dogs were anesthetized with pentobarbitone 30 mg.kg-1 and submitted to volume expansion with Ringer's solution (0.4 ml.kg-1.min-1 and mechanical ventilation with room air. In this model, the hemodynamic repercussions of the following drugs and doses were studied. pentobarbitone 5 mg.kg-1 Group 1, control - and the association of pentobarbitone and magnesium sulphate (MS), at the dose of 140 mg.kg-1 injected in 15 minutes, followed by an infusion of 80 mg.kg-1.h-1 - Group 2. The parameters studied were: heart rate, blood pressure, inferior vena cava pressure, cardiac index, systolic index and peripheral resistance index, evaluated at 5 different moments: 15(M1), 30(M2), 60(M3) and 75(M4) minutes after the first suppplementary dose of pentobarbitone and 15 minutes (M5) after the second supplementary dose. In Group 2, the moments M3, M4, M5 corresponded to 15, 30 and 60 minutes after the priming dose of magnesium sulphate. Results - Group 1 animals exhibited tachycardia since the beginning of the experiment. There was a decrease in the cardiac index, in the systolic index and an increase in the inferior vena cava pressure. Group 2 animals also exhibited tachycardia, but heart rate decreased after MS infusion. The blood pressure and the peripheral resistance index decreased. The systolic index increased and the cardiac index decreased only at the end of the experiment. Conclusions: The antiadrenergic effects of MS could have been responsible for the decrease in heart rate. The vasodilating effects of the magnesium induced the decrease in the peripheral resistance index. The systolic index increased, showing that myocardial depression did not occur.en
dc.description.affiliationDept de Anestesiologia de FMB-UNESP Distrito de Rubiao Junior, 18618-970 Botucatu - SP
dc.description.affiliationUnespDept de Anestesiologia de FMB-UNESP Distrito de Rubiao Junior, 18618-970 Botucatu - SP
dc.format.extent19-25
dc.identifierhttp://www.sba.com.br/arquivos/revista/rba/jan96019.pdf
dc.identifier.citationRevista Brasileira de Anestesiologia, v. 46, n. 1, p. 19-25, 1996.
dc.identifier.file2-s2.0-0029960922.pdf
dc.identifier.issn0034-7094
dc.identifier.lattes8226942130768820
dc.identifier.lattes8223546475724058
dc.identifier.scopus2-s2.0-0029960922
dc.identifier.urihttp://hdl.handle.net/11449/64724
dc.language.isopor
dc.relation.ispartofRevista Brasileira de Anestesiologia
dc.relation.ispartofjcr0.850
dc.relation.ispartofsjr0,320
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAnesthetic techniques, general, venous
dc.subjectAnimal, dog
dc.subjectCardiovascular system, hemodynamics
dc.subjectDrugs, magnesium sulphate, pentobarbitone
dc.subjectExperimental anesthesia
dc.subjecthypnotic sedative agent
dc.subjectmagnesium sulfate
dc.subjectpentobarbital
dc.subjectanimal experiment
dc.subjectartificial ventilation
dc.subjectblood pressure
dc.subjectcontrolled study
dc.subjectdog
dc.subjectgeneral anesthesia
dc.subjectheart hemodynamics
dc.subjectheart index
dc.subjectheart rate
dc.subjecthypermagnesemia
dc.subjectinferior cava vein
dc.subjectnonhuman
dc.subjectsystole
dc.subjecttachycardia
dc.subjectvascular resistance
dc.titleEFEIFOS DO SULFATE DE MAGNESIO NA HEMODINAMICA CARDIOVASCULAR DE CAES ANESTESIADOS COM PENTOBARBITAL SODICOpt
dc.title.alternativeEffects of magnesium sulphate on the cardiovascular hemodynamics of dogs anesthetized with pentobarbitoneen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/rba/paboutj.htm
unesp.author.lattes8226942130768820
unesp.author.lattes8223546475724058
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentAnestesiologia - FMBpt

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