Losartan (DUR-753) blocks the natriuretic, kaliuretic and antidiuretic effect of intracerebroventricular injection of carbachol in water-loaded rats
dc.contributor.author | Saad, William A. [UNESP] | |
dc.contributor.author | Luiz, A. C. [UNESP] | |
dc.contributor.author | Camargo, L. A.A. [UNESP] | |
dc.contributor.author | Renzi, A. [UNESP] | |
dc.contributor.author | Menani, J. V. [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | |
dc.contributor.institution | Universidade Esladual Paulista | |
dc.date.accessioned | 2022-04-28T19:54:22Z | |
dc.date.available | 2022-04-28T19:54:22Z | |
dc.date.issued | 1996-12-01 | |
dc.description.abstract | We determined the effect of intracerebroventricular (icv) administration of losartan, an angiotensin II (ANG II) subtype 1 receptor (AT1) antagonist, on icv carbachol-induced natriuresis, kaliuresis and antidiuresis in water-loaded male Holtzman rats (250-300 g) with a cannula implanted into the lateral ventricle (LV). The rats were water loaded with 5% of their body weight by gavage twice, with the second gavage one hour after the first. Carbachol (2 nmol in 1 μl) was injected icv immediately after the second load. When losartan (DUP-753, 50 nmol in 1 μl) was administered icv, it was given 3 min before carbachol. Previous icv treatment with losartan significantly reduced the icv carbachol-induced natriuresis (324 ± 17 μEq/120 min), kaliuresis (103 ± 15 μEq/120min) and antidiuresis (13.5 ± 2.1 ml/120 min) compared to the effects of previous icv injection of saline (Na+ excretion = 498 ± 22 μEq/120 min; K+ excretion = 167 ± 20 μEq/120 min; urine volume = 5.2 ± 1.2 ml/120 min). These results, reported as means ± SEM for 12 rats in each group, are consistent with the hypothesis that AT1 subtype receptors participate in the regulation of body electrolyte balance. | en |
dc.description.affiliation | Depto. de Cie. Fisiológicas Faculdade de Odontotogia Universidade Estadual Paulista, 14801-903 Araraquara, SP | |
dc.description.affiliation | Depto. de Cie. Fisiológicas Faculdade de Odontologia Universidade Esladual Paulista, Rua Humaitá, 1680, 14801-903 Araraquara, SP | |
dc.description.affiliationUnesp | Depto. de Cie. Fisiológicas Faculdade de Odontotogia Universidade Estadual Paulista, 14801-903 Araraquara, SP | |
dc.format.extent | 511-513 | |
dc.identifier.citation | Brazilian Journal of Medical and Biological Research, v. 29, n. 4, p. 511-513, 1996. | |
dc.identifier.issn | 0100-879X | |
dc.identifier.scopus | 2-s2.0-0029940742 | |
dc.identifier.uri | http://hdl.handle.net/11449/224030 | |
dc.language.iso | eng | |
dc.relation.ispartof | Brazilian Journal of Medical and Biological Research | |
dc.source | Scopus | |
dc.subject | Angiotensin II | |
dc.subject | AT1 receptors | |
dc.subject | Carbachol | |
dc.subject | DUP-753 | |
dc.subject | Electrolyte balance | |
dc.subject | Losartan | |
dc.title | Losartan (DUR-753) blocks the natriuretic, kaliuretic and antidiuretic effect of intracerebroventricular injection of carbachol in water-loaded rats | en |
dc.type | Artigo |