Losartan (DUR-753) blocks the natriuretic, kaliuretic and antidiuretic effect of intracerebroventricular injection of carbachol in water-loaded rats

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dc.contributor.authorSaad, William A. [UNESP]
dc.contributor.authorLuiz, A. C. [UNESP]
dc.contributor.authorCamargo, L. A.A. [UNESP]
dc.contributor.authorRenzi, A. [UNESP]
dc.contributor.authorMenani, J. V. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Esladual Paulista
dc.date.accessioned2022-04-28T19:54:22Z
dc.date.available2022-04-28T19:54:22Z
dc.date.issued1996-12-01
dc.description.abstractWe determined the effect of intracerebroventricular (icv) administration of losartan, an angiotensin II (ANG II) subtype 1 receptor (AT1) antagonist, on icv carbachol-induced natriuresis, kaliuresis and antidiuresis in water-loaded male Holtzman rats (250-300 g) with a cannula implanted into the lateral ventricle (LV). The rats were water loaded with 5% of their body weight by gavage twice, with the second gavage one hour after the first. Carbachol (2 nmol in 1 μl) was injected icv immediately after the second load. When losartan (DUP-753, 50 nmol in 1 μl) was administered icv, it was given 3 min before carbachol. Previous icv treatment with losartan significantly reduced the icv carbachol-induced natriuresis (324 ± 17 μEq/120 min), kaliuresis (103 ± 15 μEq/120min) and antidiuresis (13.5 ± 2.1 ml/120 min) compared to the effects of previous icv injection of saline (Na+ excretion = 498 ± 22 μEq/120 min; K+ excretion = 167 ± 20 μEq/120 min; urine volume = 5.2 ± 1.2 ml/120 min). These results, reported as means ± SEM for 12 rats in each group, are consistent with the hypothesis that AT1 subtype receptors participate in the regulation of body electrolyte balance.en
dc.description.affiliationDepto. de Cie. Fisiológicas Faculdade de Odontotogia Universidade Estadual Paulista, 14801-903 Araraquara, SP
dc.description.affiliationDepto. de Cie. Fisiológicas Faculdade de Odontologia Universidade Esladual Paulista, Rua Humaitá, 1680, 14801-903 Araraquara, SP
dc.description.affiliationUnespDepto. de Cie. Fisiológicas Faculdade de Odontotogia Universidade Estadual Paulista, 14801-903 Araraquara, SP
dc.format.extent511-513
dc.identifier.citationBrazilian Journal of Medical and Biological Research, v. 29, n. 4, p. 511-513, 1996.
dc.identifier.issn0100-879X
dc.identifier.scopus2-s2.0-0029940742
dc.identifier.urihttp://hdl.handle.net/11449/224030
dc.language.isoeng
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.sourceScopus
dc.subjectAngiotensin II
dc.subjectAT1 receptors
dc.subjectCarbachol
dc.subjectDUP-753
dc.subjectElectrolyte balance
dc.subjectLosartan
dc.titleLosartan (DUR-753) blocks the natriuretic, kaliuretic and antidiuretic effect of intracerebroventricular injection of carbachol in water-loaded ratsen
dc.typeArtigo

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