Anestésicos locais: interação com membranas biológicas e com o canal de sódio voltagem-dependente

Araujo, Daniele Ribeiro de; Paula, Eneida de; Fraceto, Leonardo Fernandes [UNESP]

Anestésicos locais: interação com membranas biológicas e com o canal de sódio voltagem-dependente

Arquivos

S0100-40422008000700032.pdf (976.23 KB)

Data

2008-01-01

Autores

Araujo, Daniele Ribeiro de

Paula, Eneida de

Fraceto, Leonardo Fernandes

Editor

Sociedade Brasileira de Química

Tipo

Artigo

Direito de acesso

Acesso aberto

Resumo

Many theories about the mechanism of action of local anesthetics (LA) are described in the literature. Two types of theories can be distinguished: those that focus on the direct effects of LA on their target protein in the axon membranes, i.e. the voltage-gated sodium channel and the ones that take into account the interaction of anesthetic molecules with the lipid membrane phase for the reversible nerve blockage. Since there is a direct correlation between LA hydrophobicity and potency, it is crucial to take this physico-chemical property into account to understand the mechanism of action of LA, be it on the sodium channel protein, lipid(s), or on the whole membrane phase.