Sex differences in breathing

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dc.contributor.authorGargaglioni, Luciane H. [UNESP]
dc.contributor.authorMarques, Danuzia A. [UNESP]
dc.contributor.authorPatrone, Luis Gustavo A. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-06T16:45:51Z
dc.date.available2019-10-06T16:45:51Z
dc.date.issued2019-12-01
dc.description.abstractBreathing is a vital behavior that ensures both the adequate supply of oxygen and the elimination of CO2, and it is influenced by many factors. Despite that most of the studies in respiratory physiology rely heavily on male subjects, there is much evidence to suggest that sex is an important factor in the respiratory control system, including the susceptibility for some diseases. These different respiratory responses in males and females may be related to the actions of sex hormones, especially in adulthood. These hormones affect neuromodulatory systems that influence the central medullary rhythm/pontine pattern generator and integrator, sensory inputs to the integrator and motor output to the respiratory muscles. In this article, we will first review the sex dependence on the prevalence of some respiratory-related diseases. Then, we will discuss the role of sex and gonadal hormones in respiratory control under resting conditions and during respiratory challenges, such as hypoxia and hypercapnia, and whether hormonal fluctuations during the estrous/menstrual cycle affect breathing control. We will then discuss the role of the locus coeruleus, a sexually dimorphic CO2/pH-chemosensitive nucleus, on breathing regulation in males and females. Next, we will highlight the studies that exist regarding sex differences in respiratory control during development. Finally, the few existing studies regarding the influence of sex on breathing control in non-mammalian vertebrates will be discussed.en
dc.description.affiliationDepartment of Animal Morphology and Physiology FCAVJ-UNESP-São Paulo State University
dc.description.affiliationUnespDepartment of Animal Morphology and Physiology FCAVJ-UNESP-São Paulo State University
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCNPq: 140715/2015-0
dc.description.sponsorshipIdFAPESP: 2016/04276-9
dc.description.sponsorshipIdFAPESP: 2016/24577-3
dc.description.sponsorshipIdFAPESP: 2017/05318-0
dc.description.sponsorshipIdFAPESP: 2019/09469-8
dc.description.sponsorshipIdCNPq: 407490/2018-3
dc.identifierhttp://dx.doi.org/10.1016/j.cbpa.2019.110543
dc.identifier.citationComparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology, v. 238.
dc.identifier.doi10.1016/j.cbpa.2019.110543
dc.identifier.issn1531-4332
dc.identifier.issn1095-6433
dc.identifier.scopus2-s2.0-85071726097
dc.identifier.urihttp://hdl.handle.net/11449/189600
dc.language.isoeng
dc.relation.ispartofComparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAmphibian
dc.subjectMammals
dc.subjectRespiration
dc.subjectSex hormones
dc.subjectSexual dimorphism
dc.titleSex differences in breathingen
dc.typeResenha

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Artigos - Morfologia e Fisiologia Animal - FCAV