Methacycline: A Review of Analytical Methods

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dc.contributor.authorda Silva, Lucclia M. [UNESP]
dc.contributor.authorSalgado, Hérida Regina Nunes [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:24:52Z
dc.date.available2014-05-20T13:24:52Z
dc.date.issued2012-02-01
dc.description.abstractMethacycline is a broad spectrum, semisynthetic antibiotic prepared from oxytetracycline. Its antibacterial spectrum is as same as that of tetracycline, but its efficacy is superior to that of oxytetracycline and tetracycline. There is no standard technique for analysis and/or detection of methacycline. Practical requirements for high-sensitivity analysis and the need for a specialist laboratory setting create challenges for routine analysis. Several existing analytical techniques, which offer flexible and broad-based methods of analysis and detection, have been discussed in this manuscript, focusing on bioanalytical, pharmaceutical QC applications and food analysis. This review will examine the published analytical methods reported for determination of methacycline, presenting (a) sample pretreatment methods such as liquid-liquid extraction (LLE) and solid phase extraction (SPE), (b) separation methods such as thin layer chromatography, high performance liquid chromatography (HPLC) and capillary electrophoresis (CE) and (c) others such as potentiometry, spectrophotometry and microbiological assay, from which it can be seen that HPLC methods have been used most extensively.en
dc.description.affiliationUNESP, Programa Posgrad Ciencias Farmaceut, Fac Ciencias Farmaceut Araraquara, Sch Pharmaceut Sci Araraquara, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUNESP, Dept Drugs & Med, Sch Pharmaceut Sci Araraquara, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Programa Posgrad Ciencias Farmaceut, Fac Ciencias Farmaceut Araraquara, Sch Pharmaceut Sci Araraquara, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Dept Drugs & Med, Sch Pharmaceut Sci Araraquara, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipPrograma de Apoio ao Desenvolvimento Científico da Faculdade de Ciências Farmacêuticas da UNESP (PADC)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipFundação para o Desenvolvimento da UNESP (FUNDUNESP)
dc.identifierhttp://dx.doi.org/10.2174/157341212798995494
dc.identifier.citationCurrent Pharmaceutical Analysis. Sharjah: Bentham Science Publ Ltd, v. 8, n. 1, p. 2-13, 2012.
dc.identifier.doi10.2174/157341212798995494
dc.identifier.issn1573-4129
dc.identifier.urihttp://hdl.handle.net/11449/7836
dc.identifier.wosWOS:000300589400002
dc.language.isoeng
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCurrent Pharmaceutical Analysis
dc.relation.ispartofjcr0.859
dc.relation.ispartofsjr0,224
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAnalytical methodsen
dc.subjectBroad spectrum antibioticen
dc.subjectMethacyclineen
dc.subjectTetracyclinesen
dc.titleMethacycline: A Review of Analytical Methodsen
dc.typeResenha
dcterms.licensehttp://www.benthamscience.com/permission.php
dcterms.rightsHolderBentham Science Publ Ltd
unesp.author.orcid0000-0002-0385-340X[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentFármacos e Medicamentos - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas