Preparação e caracterização físico-química de complexos de inclusão entre anestésicos locais e hidroxipropil-beta-ciclodextrina

Moraes, Carolina Morales; Abrami, Priscila; Gonçalves, Marcos Moisés; Andréo Filho, Newton; Fernandes, Sérgio Antonio; Paula, Eneida de; Fraceto, Leonardo Fernandes [UNESP]

Preparação e caracterização físico-química de complexos de inclusão entre anestésicos locais e hidroxipropil-beta-ciclodextrina

Arquivos

S0100-40422007000400005.pdf (437.7 KB)

Data

2007-08-01

Autores

Moraes, Carolina Morales

Abrami, Priscila

Gonçalves, Marcos Moisés

Andréo Filho, Newton

Fernandes, Sérgio Antonio

Paula, Eneida de

Fraceto, Leonardo Fernandes

Editor

Sociedade Brasileira de Química

Tipo

Artigo

Direito de acesso

Acesso aberto

Resumo

S(-) Bupivacaine (S(-)BVC) and Lidocaine (LDC) are widely used local anesthetics (LA). Hydroxypropyl beta-cyclodextrin (HP-beta-CD) is used as a drug-carrier system. The aim of this work was to characterize inclusion complexes between LA and HP-beta-CD. The affinity constants determined at different pHs show favourable complexation. The release kinetics experiments showed that S(-)BVC and LDC changed the released profiles in the presence of HP-beta-CD. Nuclear magnetic resonance experiments gave information about the interaction between LA and the cyclodextrin cavity. This study focused on the physicochemical characterization of drug-delivery formulations that come out as potentially new therapeutic options for pain treatment.