Effect of simvastatin on the generation of autoantibodies against oxidized LDL and progression of atherosclerosis in rabbits

dc.contributor.authorCavallini, Daniela Cardoso Umbelino [UNESP]
dc.contributor.authorAbdalla, Dulcineia S. P.
dc.contributor.authorPauly-Silveira, Nadiege D. [UNESP]
dc.contributor.authorRossi, Elizeu Antonio [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T13:23:41Z
dc.date.available2014-05-20T13:23:41Z
dc.date.issued2010-12-01
dc.description.abstractOxidized Low-Density Lipoproteins (oxLDL) and autoantibodies against oxLDL are important in the development of atherosclerotic lesions. Statins are efficacious in the control of dyslipidemia and prevention of atherosclerosis; however, many questions concerning the mechanism of action of such drugs remain unknown. This work investigated the effect of simvastatin on generation of autoantibodies against oxLDL and development of atherosclerosis in rabbits. The animals were divided into three groups: control, hypercholesterolemic, and hypercholesterolemic simvastatin (3.0 mg simvastatin/ kg body weight). Concentrations of autoantibodies against oxLDL were determined on days 0,30 and 60 of the experiment and the atherosclerotic lesions were evaluated at the end of the study. Simvastatin reduced intimal proliferation in the thoracic region, prevented arterial calcification and inhibited the generation of autoantibodies against oxLDL. In conclusion, daily administration of simvastatin slows down atherosclerotic lesion development in rabbits with induced hypercholesterolemia and inhibition on generation of autoantibodies against oxLDL contributes to the cardioprotective effect observed.en
dc.description.affiliationSão Paulo State Univ, Fac Pharmaceut Sci, Dept Food & Nutr, Araraquara, SP, Brazil
dc.description.affiliationUniv São Paulo, Fac Pharmaceut Sci, Dept Clin & Toxicol Anal, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Fac Pharmaceut Sci, Dept Food & Nutr, Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent1419-1424
dc.identifier.citationLatin American Journal of Pharmacy. La Plata: Colegio Farmaceuticos Provincia de Buenos Aires, v. 29, n. 8, p. 1419-1424, 2010.
dc.identifier.issn0326-2383
dc.identifier.lattes3242858535763793
dc.identifier.urihttp://hdl.handle.net/11449/7193
dc.identifier.wosWOS:000288060000022
dc.language.isoeng
dc.publisherColegio Farmaceuticos Provincia de Buenos Aires
dc.relation.ispartofLatin American Journal of Pharmacy
dc.relation.ispartofjcr0.401
dc.relation.ispartofsjr0,152
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAtherosclerosisen
dc.subjectAutoantibodies against oxidized LDLen
dc.subjectSimvastatinen
dc.titleEffect of simvastatin on the generation of autoantibodies against oxidized LDL and progression of atherosclerosis in rabbitsen
dc.typeArtigo
dcterms.rightsHolderColegio Farmaceuticos Provincia de Buenos Aires
unesp.author.lattes3242858535763793
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentAlimentos e Nutrição - FCFpt

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