Efeitos da associação da clonidina à ropivacaína na anestesia peridural

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dc.contributor.authorAzevedo Alves, Túlio César [UNESP]
dc.contributor.authorCerqueira Braz, José Reinaldo [UNESP]
dc.contributor.institutionBA. Responsável Pelo CET/SBA da AOSID
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-28T19:55:30Z
dc.date.available2022-04-28T19:55:30Z
dc.date.issued2002-08-14
dc.description.abstractBackground and Objectives - Clinical effects and the potential synergism between clonidine an α 2-adrenergic agonist and ropivacaine have not been studied in patients undergoing epidural anesthesia. This research aimed at clinically evaluating clonidine associated to ropivacaine for epidural anesthesia. Methods - Participated in this double-blind study 60 patients of both genders who were distributed in two groups: G control = epidural 0.75% ropivacaine (150 mg); G clonidine = epidural 0.75% ropivacaine (150 mg) plus clonidine (300 μg). The following parameters were studied: total analgesic block (onset time), motor block onset, analgesic and motor block duration upper level of analgesia, consciousness level, need for intraoperative analgesia and supplemental sedation, peri and postoperative arterial hypotension, intensity of postoperative pain, analgesia duration, and side-effects. Results - Epidural clonidine (300 μg) had not affected onset (p > 0.05) but has prolonged sensory and motor block duration (p < 0.0007) and postoperative analgesia (p > 0.001). Arterial hypotension rate was the same for both groups, but the incidence of bradycardia and sedation was higher in the clonidine group (p < 0.02 and p < 0.001 respectively). Shivering was more common in the control group (p < 0.001). Conclusions - In the conditions of our study there has been a clear synergism between epidural clonidine and ropivacaine. Clonidine increases sensory and motor block duration during epidural anesthesia with ropivacaine and prolongs postoperative analgesia. Additional advantages of clonidine are increased sedation and decreased shivering, but its drawback is to increase the incidence of bradycardia.en
dc.description.affiliationFarmacologia da Escola de Medicina e Saúde Pública de Salvador BA. Responsável Pelo CET/SBA da AOSID
dc.description.affiliationCET/SBA Departamento de Anestesiologia da FMB UNESP
dc.description.affiliationDepto de Anestesiologia da FMB UNESP, 18618-970 Botucatu, SP
dc.description.affiliationUnespCET/SBA Departamento de Anestesiologia da FMB UNESP
dc.description.affiliationUnespDepto de Anestesiologia da FMB UNESP, 18618-970 Botucatu, SP
dc.format.extent410-419
dc.identifier.citationRevista Brasileira de Anestesiologia, v. 52, n. 4, p. 410-419, 2002.
dc.identifier.issn0034-7094
dc.identifier.scopus2-s2.0-0036330382
dc.identifier.urihttp://hdl.handle.net/11449/224250
dc.language.isopor
dc.language.isoeng
dc.relation.ispartofRevista Brasileira de Anestesiologia
dc.sourceScopus
dc.subjectAnalgesics: clonidine
dc.subjectAnesthetic techniques, Regional: epidural block
dc.subjectAnesthetics: Local, ropivacaine
dc.titleEfeitos da associação da clonidina à ropivacaína na anestesia periduralpt
dc.title.alternativeClinical evaluation of clonidine associated to ropivacaine for epidural anesthesiaen
dc.typeArtigo
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentAnestesiologia - FMBpt

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