Candida–Bacterial Biofilms and Host–Microbe Interactions in Oral Diseases

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dc.contributor.authorNegrini, Thais de Cássia [UNESP]
dc.contributor.authorKoo, Hyun
dc.contributor.authorArthur, Rodrigo Alex
dc.contributor.institutionUniversity of Pennsylvania
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionFederal University of Rio Grande do Sul (UFRGS)
dc.date.accessioned2020-12-12T01:46:12Z
dc.date.available2020-12-12T01:46:12Z
dc.date.issued2019-01-01
dc.description.abstractOral cavity harbors a complex and highly diverse microbial community. Cross-kingdom interactions between Candida and oral bacteria are critical for their co-existence, which may also affect the course and the severity of biofilm-mediated bacterial-mediated diseases. C. albicans has been found in polymicrobial biofilms associated with denture stomatitis, oral mucositis, dental caries, periodontal diseases, peri-implantitis, and root canal infection. Thus, it is of utmost importance to unravel the mechanisms of Candida–bacterial interactions and their impact on the onset and severity of cross-kingdom biofilm-related diseases. Here, we highlight the potential role of Candida–bacterial biofilm interactions in the pathogenesis of oral diseases, especially mucosal infections and dental caries. The influence of Candida–bacterial biofilms on the mucosal host immune response is also discussed. Finally, we present some of the current and prospective therapeutic strategies for controlling these cross-kingdom interactions and their virulence properties associated with oral diseases.en
dc.description.affiliationBiofilm Research Laboratory Department of Orthodontics and Divisions of Pediatric Dentistry and Community Oral Health School of Dental Medicine University of Pennsylvania
dc.description.affiliationDepartment of Clinical Analysis School of Pharmaceutical Sciences São Paulo State University (UNESP)
dc.description.affiliationPreventive and Community Dentistry Department Dental School Federal University of Rio Grande do Sul (UFRGS)
dc.description.affiliationUnespDepartment of Clinical Analysis School of Pharmaceutical Sciences São Paulo State University (UNESP)
dc.format.extent119-141
dc.identifierhttp://dx.doi.org/10.1007/978-3-030-28524-1_10
dc.identifier.citationAdvances in Experimental Medicine and Biology, v. 1197, p. 119-141.
dc.identifier.doi10.1007/978-3-030-28524-1_10
dc.identifier.issn2214-8019
dc.identifier.issn0065-2598
dc.identifier.scopus2-s2.0-85075190470
dc.identifier.urihttp://hdl.handle.net/11449/199672
dc.language.isoeng
dc.relation.ispartofAdvances in Experimental Medicine and Biology
dc.sourceScopus
dc.titleCandida–Bacterial Biofilms and Host–Microbe Interactions in Oral Diseasesen
dc.typeCapítulo de livro
unesp.departmentAnálises Clínicas - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas