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Oral clefts and vitamin supplementation

dc.contributor.authorLoffredo, LCM
dc.contributor.authorSouza, JMP
dc.contributor.authorFreitas, JAS
dc.contributor.authorMossey, P. A.
dc.contributor.institutionUniv Dundee
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:25:25Z
dc.date.available2014-05-20T15:25:25Z
dc.date.issued2001-01-01
dc.description.abstractObjectives: the evidence linking low levels of folic acid and orofacial clefting (OFC) is presently equivocal, There is stronger evidence for the role of folic acid supplementation in protection against the occurrence and recurrence of neural tube defects. The present investigation tested the hypotheses that cleft lip, cleft palate, or both are inversely associated with maternal intake of dietary and supplemental vitamins during the periconceptional period and first 4 months of pregnancy in a Brazilian population.Design: A population-based, case-control study of cleft lip with or without cleft palate (CL(P)) and isolated cleft palate (CP) in a Brazilian population. in structured interviews, case histories were taken from the mothers of a consecutive sample of 450 infants born with nonsyndromic OFC,Results: Mothers who had children with CL(P) were less likely to have been supplemented during the periconceptional period. The statistical significance of the difference in prevalence of the use of supplements between mothers of patients and of controls was greater for the CL(P) group: p < .05 for CP and p < .001 for CL(P). Multivariate analysis confirmed this finding of a protective effect for both types of orofacial cleft,Conclusions: the use of vitamin supplements in the first 4 months of pregnancy was suggestive of a protective effect against the occurrence of CP and CL(P) in this population, the significance of an association between multivitamin supplementation and OFC and the possible role of gene/environment interaction are discussed.en
dc.description.affiliationUniv Dundee, Sch Dent, Unit Dent & Oral Hlth, Dundee, Scotland
dc.description.affiliationUSP, Hosp Pesquisa & Reabilitacao Lesoes, Labio Palatais, Brazil
dc.description.affiliationUSP, Fac Saúde Publ, São Paulo, Brazil
dc.description.affiliationUNESP, Fac Odontol Araraquara, São Paulo, Brazil
dc.description.affiliationUnespUNESP, Fac Odontol Araraquara, São Paulo, Brazil
dc.format.extent76-83
dc.identifierhttp://dx.doi.org/10.1597/1545-1569(2001)038<0076:OCAVS>2.0.CO;2
dc.identifier.citationCleft Palate-craniofacial Journal. Chapel Hill: Amer Cleft Palate-craniofacial Assoc, v. 38, n. 1, p. 76-83, 2001.
dc.identifier.doi10.1597/1545-1569(2001)038<0076:OCAVS>2.0.CO;2
dc.identifier.issn1055-6656
dc.identifier.urihttp://hdl.handle.net/11449/35849
dc.identifier.wosWOS:000166533400013
dc.language.isoeng
dc.publisherAmer Cleft Palate-craniofacial Assoc
dc.relation.ispartofCleft Palate-craniofacial Journal
dc.relation.ispartofsjr0,757
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectcleft lip and palatept
dc.subjectcleft palatept
dc.subjectpregnancypt
dc.subjectvitamin supplementationpt
dc.titleOral clefts and vitamin supplementationen
dc.typeArtigo
dcterms.licensehttp://www.cpcjournal.org/userimages/ContentEditor/1305055520771/copyrighttransfer.pdf
dcterms.rightsHolderAmer Cleft Palate-craniofacial Assoc

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