Optimization and application of imprinted poly(AA-EGDMA) for solid phase extraction of ciprofloxacin in artificial urine

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dc.contributor.authorMarestoni, Luis D. [UNESP]
dc.contributor.authorWong, Ademar [UNESP]
dc.contributor.authorFeliciano, Gustavo T. [UNESP]
dc.contributor.authorMarchi, Mary R. R. [UNESP]
dc.contributor.authorTarley, Cesar R. T.
dc.contributor.authorDel Pilar Taboada Sotomayor, Maria [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionFederal Institute of Paraná
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.date.accessioned2022-04-28T19:01:07Z
dc.date.available2022-04-28T19:01:07Z
dc.date.issued2015-06-01
dc.description.abstractCiprofloxacin is one of the most widely used antibiotics and knowledge of concentration in the urine is of great significance for pharmacokinetic and environmental studies. In this work, the Poly (Acrylic Acid – Ethylene Glycol Dimethacrylate) Molecularly Imprinted Polymer was optimized as a adsorbent in solid phase extraction (MISPE) for Ciprofloxacin. It is desirable because they are adsorbent materials highly selective to their template molecule. The MIP resulted in maximum sorption capacities of 282 μmol g-1 in batch studies and in μmol g-1 in the breakthrough curve studies. MISPE was applied in synthetic urine to test its viability. The limit of detection was 70 ng mL-1. The enrichment factor of the method was 5.32, and recovery in urine ranged from 94.2% to 120.8%. These results showed the applicability of this optimized MISPE.en
dc.description.affiliationInstitute of Chemistry São Paulo State University, Prof. Francisco Degni Street, 55
dc.description.affiliationFederal Institute of Paraná, Highway PR160, km19.5
dc.description.affiliationDepartment of Chemistry State University of Londrina, Highway Celso Garcia Cid, km380
dc.description.affiliationUnespInstitute of Chemistry São Paulo State University, Prof. Francisco Degni Street, 55
dc.format.extent270-276
dc.identifierhttp://dx.doi.org/10.2174/1574885510999150505160637
dc.identifier.citationCurrent Drug Therapy, v. 9, n. 4, p. 270-276, 2015.
dc.identifier.doi10.2174/1574885510999150505160637
dc.identifier.issn1065-7630
dc.identifier.issn1574-8855
dc.identifier.scopus2-s2.0-84930517997
dc.identifier.urihttp://hdl.handle.net/11449/220377
dc.language.isoeng
dc.relation.ispartofCurrent Drug Therapy
dc.sourceScopus
dc.subjectCiprofloxacin
dc.subjectMolecularly imprinted polymers
dc.subjectOptimization
dc.subjectSolid phase extraction
dc.titleOptimization and application of imprinted poly(AA-EGDMA) for solid phase extraction of ciprofloxacin in artificial urineen
dc.typeArtigo

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