Asymptomatic HIV People Present Different Profiles of sCD14, sRAGE, DNA Damage, and Vitamins, according to the Use of cART and CD4(+) T Cell Restoration

Tasca, Karen Ingrid [UNESP]; Correa, Camila Renata [UNESP]; Caleffi, Juliana Trindade [UNESP]; Mendes, Monica Banwart [UNESP]; Gatto, Mariana [UNESP]; Manfio, Vanessa Martinez [UNESP]; Camargo, Caio Cavassan de [UNESP]; Tavares, Francilene Capel [UNESP]; Biasin, Mara; Souza, Lenice do Rosario de [UNESP]

Asymptomatic HIV People Present Different Profiles of sCD14, sRAGE, DNA Damage, and Vitamins, according to the Use of cART and CD4(+) T Cell Restoration

Arquivos

WOS000430602000001.pdf (2.26 MB)

Data

2018-01-01

Autores

Tasca, Karen Ingrid

Correa, Camila Renata

Caleffi, Juliana Trindade

Mendes, Monica Banwart

Gatto, Mariana

Manfio, Vanessa Martinez

Camargo, Caio Cavassan de

Tavares, Francilene Capel

Biasin, Mara

Souza, Lenice do Rosario de

Editor

Hindawi Ltd

Tipo

Artigo

Direito de acesso

Acesso aberto

Resumo

We aimed to analyze markers of immune activation, inflammation, and oxidative stress in 92 asymptomatic HIV-infected patients according to the adequate (AR, >500 cells/mm(3)) or inadequate (IR, <500 cells/mm(3)) CD4(+) T recovery and the presence or absence of antiretroviral treatment (cART). In relation to those newly diagnosed, they were divided into two groups, cART-naive IR (nIR) and cART-naive AR (nAR). Among those diagnosed more than five years ago, the following division was made: the cART-naive long-term nonprogressors (LTNP); patient under cART and AR (tAR); and patients under cART and IR (tIR). We investigated the expression of soluble receptor for advanced glycation end products (sRAGE), high-mobility group-box protein -1 (HMGB1), soluble CD14 (sCD14), IL-8, IL-10, 8-isoprostane, vitamins, and DNA damage. We observed higher levels of sRAGE in tAR as compared to nIR, nAR, LTNP, and more sCD14 than in nIR and nAR. As for IL-10 levels, we found nIR > nAR > LTNP > tAR > tIR. Higher levels of 8-isoprostane were observed in nIR. LTNP presented a higher retinol dosage than tAR and less genotoxic damage induced by oxidative stress than the other groups. We suggest that the therapy, despite being related to lesser immune activation and inflammation, alters the vitamin profile and consequently increases the oxidative stress of patients. In addition, the lowest genotoxic index for LTNP indicates that both VL and cART could be responsible for the increased DNA damage. More studies are needed to understand the influence of cART on persistent immune activation and inflammation.