Mushroom-derived preparations in the prevention of H2O2-induced oxidative damage to cellular DNA

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Rocha, Noeme Sousa [UNESP]
Barbisan, Luis Fernando [UNESP]
De Oliveira, Maria Luiza Cotrim [UNESP]
De Camargo, Joo Lauro Viana [UNESP]
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Aqueous extracts of the sporophores of eight mushroom species were assessed for their ability to prevent H2O2-induced oxidative damage to cellular DNA using the single-cell gel electrophoresis (Comet) assay. The highest genoprotective effects were obtained with cold (20°C) and hot (100°C) water extracts of Agaricus bisporus and Ganoderma lucidum fruit bodies, respectively. No protective effects were observed with Mushroom Derived Preparations (MDPs) from Flammulina velutipes, Auricularia auricula, Hypsizygus marmoreus, Lentinula edodes, Pleurotus sajor-caju, and Volvariella volvacea. These findings indicate that some edible mushrooms represent a valuable source of biologically active compounds with potential for protecting cellular DNA from oxidative damage. © 2002 Wiley-Liss, Inc.
Agaricus bisporus, Anti-oxidants, Comet assay, Ganoderrna lucidum, Reactive oxygen species, agaricus bisporus extract, Auricularia auricula extract, flammulina velutipes extract, Ganoderma lucidum extract, hydrogen peroxide, hypsizygus mormoreus extract, lentinuloa edodes extract, leurotus sajor caju extract, mushroom derivative preparation, mushroom extract, plant extract, unclassified drug, volvariella volvacea extract, antioxidant activity, DNA damage, gel electrophoresis, Hong Kong, human, human cell, mushroom, mutagenesis, oxidative stress, priority journal, Agaricales, Comet Assay, DNA Damage, DNA, Neoplasm, Fungal Proteins, Hydrogen Peroxide, Mutagenicity Tests, Oxidation-Reduction, Oxidative Stress, Reactive Oxygen Species, Tumor Cells, Cultured, Agaricus, Auricula, Auricularia auricula-judae, Basidiomycota, Flammulina, Flammulina velutipes, Ganoderma, Ganoderma lucidum, Hypsizygus, Hypsizygus marmoreus, Lentinula, Lentinula edodes, Pleurotus, Pleurotus sajor-caju, Volvariella volvacea
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Teratogenesis Carcinogenesis and Mutagenesis, v. 22, n. 2, p. 103-111, 2002.