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Prostaglandin E-2 and the Suppression of Phagocyte Innate Immune Responses in Different Organs

dc.contributor.authorMedeiros, Alexandra Ivo de [UNESP]
dc.contributor.authorPeres-Buzalaf, Camila
dc.contributor.authorVerdan, Felipe Fortino [UNESP]
dc.contributor.authorHenrique Serezani, C.
dc.contributor.institutionIndiana University
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T13:24:05Z
dc.date.available2014-05-20T13:24:05Z
dc.date.issued2012-01-01
dc.description.abstractThe local and systemic production of prostaglandin E-2 (PGE(2)) and its actions in phagocytes lead to immunosuppressive conditions. PGE2 is produced at high levels during inflammation, and its suppressive effects are caused by the ligation of the E prostanoid receptors EP2 and EP4, which results in the production of cyclic AMP. However, PGE(2) also exhibits immunostimulatory properties due to binding to EP3, which results in decreased cAMP levels. The various guanine nucleotide-binding proteins (G proteins) that are coupled to the different EP receptors account for the pleiotropic roles of PGE(2) in different disease states. Here, we discuss the production of PGE(2) and the actions of this prostanoid in phagocytes from different tissues, the relative contribution of PGE(2) to the modulation of innate immune responses, and the novel therapeutic opportunities that can be used to control inflammatory responses.en
dc.description.affiliationIndiana Univ, Sch Med, Dept Microbiol & Immunol, Indianapolis, IN 46202 USA
dc.description.affiliationSão Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Biol Sci, BR-14801902 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Bauru Sch Dent, Dept Biol Sci, BR-17012901 São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Biol Sci, BR-14801902 São Paulo, Brazil
dc.format.extent13
dc.identifierhttp://dx.doi.org/10.1155/2012/327568
dc.identifier.citationMediators of Inflammation. New York: Hindawi Publishing Corporation, p. 13, 2012.
dc.identifier.doi10.1155/2012/327568
dc.identifier.fileWOS000309044800001.pdf
dc.identifier.issn0962-9351
dc.identifier.urihttp://hdl.handle.net/11449/7391
dc.identifier.wosWOS:000309044800001
dc.language.isoeng
dc.publisherHindawi Publishing Corporation
dc.relation.ispartofMediators of Inflammation
dc.relation.ispartofjcr3.549
dc.relation.ispartofsjr1,370
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleProstaglandin E-2 and the Suppression of Phagocyte Innate Immune Responses in Different Organsen
dc.typeArtigo
dcterms.licensehttp://www.hindawi.com/journals/apm/apc/
dcterms.rightsHolderHindawi Publishing Corporation
unesp.author.lattes8756770929017974[1]
unesp.author.orcid0000-0001-6048-3647[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentCiências Biológicas - FCFpt

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