Prostaglandin E-2 and the Suppression of Phagocyte Innate Immune Responses in Different Organs
dc.contributor.author | Medeiros, Alexandra Ivo de [UNESP] | |
dc.contributor.author | Peres-Buzalaf, Camila | |
dc.contributor.author | Verdan, Felipe Fortino [UNESP] | |
dc.contributor.author | Henrique Serezani, C. | |
dc.contributor.institution | Indiana University | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Universidade de São Paulo (USP) | |
dc.date.accessioned | 2014-05-20T13:24:05Z | |
dc.date.available | 2014-05-20T13:24:05Z | |
dc.date.issued | 2012-01-01 | |
dc.description.abstract | The local and systemic production of prostaglandin E-2 (PGE(2)) and its actions in phagocytes lead to immunosuppressive conditions. PGE2 is produced at high levels during inflammation, and its suppressive effects are caused by the ligation of the E prostanoid receptors EP2 and EP4, which results in the production of cyclic AMP. However, PGE(2) also exhibits immunostimulatory properties due to binding to EP3, which results in decreased cAMP levels. The various guanine nucleotide-binding proteins (G proteins) that are coupled to the different EP receptors account for the pleiotropic roles of PGE(2) in different disease states. Here, we discuss the production of PGE(2) and the actions of this prostanoid in phagocytes from different tissues, the relative contribution of PGE(2) to the modulation of innate immune responses, and the novel therapeutic opportunities that can be used to control inflammatory responses. | en |
dc.description.affiliation | Indiana Univ, Sch Med, Dept Microbiol & Immunol, Indianapolis, IN 46202 USA | |
dc.description.affiliation | São Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Biol Sci, BR-14801902 São Paulo, Brazil | |
dc.description.affiliation | Univ São Paulo, Bauru Sch Dent, Dept Biol Sci, BR-17012901 São Paulo, Brazil | |
dc.description.affiliationUnesp | São Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Biol Sci, BR-14801902 São Paulo, Brazil | |
dc.format.extent | 13 | |
dc.identifier | http://dx.doi.org/10.1155/2012/327568 | |
dc.identifier.citation | Mediators of Inflammation. New York: Hindawi Publishing Corporation, p. 13, 2012. | |
dc.identifier.doi | 10.1155/2012/327568 | |
dc.identifier.file | WOS000309044800001.pdf | |
dc.identifier.issn | 0962-9351 | |
dc.identifier.uri | http://hdl.handle.net/11449/7391 | |
dc.identifier.wos | WOS:000309044800001 | |
dc.language.iso | eng | |
dc.publisher | Hindawi Publishing Corporation | |
dc.relation.ispartof | Mediators of Inflammation | |
dc.relation.ispartofjcr | 3.549 | |
dc.relation.ispartofsjr | 1,370 | |
dc.rights.accessRights | Acesso aberto | |
dc.source | Web of Science | |
dc.title | Prostaglandin E-2 and the Suppression of Phagocyte Innate Immune Responses in Different Organs | en |
dc.type | Artigo | |
dcterms.license | http://www.hindawi.com/journals/apm/apc/ | |
dcterms.rightsHolder | Hindawi Publishing Corporation | |
unesp.author.lattes | 8756770929017974[1] | |
unesp.author.orcid | 0000-0001-6048-3647[1] | |
unesp.campus | Universidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquara | pt |
unesp.department | Ciências Biológicas - FCF | pt |
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