HORMONAL AND METABOLIC STUDY OF A CASE OF ADIPOSIS-DOLOROSA (DERCUMS DISEASE)
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Pimenta, W. P.
Piccinato, C. E.
Kettelhut, I. C.
Foss, M. C.
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Associação Brasileira de Divulgação Científica (ABRADIC)
A case of a 43-year-old nonobese woman with adiposis dolorosa (Dercum's disease) is reported. Muscle glucose uptake and oxidation before and after ingestion of 75 g of glucose were similar to control group values, although a greater insulin release (16,578 vs 6,242 +/- 1,136 muU/3 h) occurred simultaneously. In vitro studies of abdominal normal and painful subcutaneous adipose tissue of the patient revealed lower responsiveness to norepinephrine and lack of response to the antilipolytic effect of insulin in the painful adipose tissue (0.98 vs 1.43 muM FFA/10(6) cells at 5.0 muM of norepinephrine). The disease was not correlated with the HLA system and there were no alterations in hormonal secretion at the pituitary, adrenal, gonadal, and thyroid levels. These findings indicate the presence of peripheral insulin resistance in this patient with adiposis dolorosa.
ADIPOSIS DOLOROSA, INSULIN RESISTANCE, GLUCOSE METABOLISM, HORMONAL SECRETION, ADIPOSE TISSUE
Brazilian Journal of Medical and Biological Research. São Paulo: Associação Bras Divulg Cientifica, v. 25, n. 9, p. 889-893, 1992.