In vitro dentin permeability and tubule occlusion of experimental in-office desensitizing materials

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dc.contributor.authorde Castro Oliveira, Laryssa [UNESP]
dc.contributor.authorMarchetti, Vitória Marega [UNESP]
dc.contributor.authorde Souza e Silva Ramos, Fernanda [UNESP]
dc.contributor.authorDelbem, Alberto Carlos Botazzo [UNESP]
dc.contributor.authorSouza, Marina Trevelin
dc.contributor.authorGanss, Bernhard
dc.contributor.authorTheodoro, Leticia Helena [UNESP]
dc.contributor.authorFagundes, Ticiane Cestari [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionUniversity of Toronto
dc.date.accessioned2023-07-29T15:12:53Z
dc.date.available2023-07-29T15:12:53Z
dc.date.issued2023-03-01
dc.description.abstractObjectives: This study investigates the dentin permeability (by hydraulic conductance) and tubule occlusion (by confocal and scanning electron microscopies) of in-office desensitizing materials. Materials and methods: Bovine dentin blocks were immersed in EDTA to open dentinal tubules. Placebo varnish (PLA), fluoride varnish (FLU), NaF 5% + 5% nanoparticulate sodium trimetaphosphate varnish (TMP), universal adhesive system (SBU), S-PRG filler varnish (SPRG), Biosilicate (BIOS), and amelotin (AMTN) solution were the materials tested. After application, the specimens underwent an erosive-abrasive challenge. Dentin permeability was evaluated at T0 (initial), T1 (after treatment), and T2 (after challenge). Confocal and scanning electron microscopy (SEM) were used to evaluate, respectively, length and number of dentinal tubule occlusions and opened dentinal tubules, after challenge. Permeability and SEM data were analyzed by two-way repeated measures ANOVA and Tukey’s tests. Confocal data were analyzed by one-way ANOVA, Tukey’s test, and Kruskal–Wallis and Dunn’s tests. Spearman and Pearson’s correlation tests were also used. Significance level was set at 5%. Results: At T1, the AMTN group showed the lowest permeability value, following the increasing order at T2: AMTN = SBU < BIOS = SPRG < TMP < FLU < PLA. The SBU group had the highest value of occluded dentinal tubule length. The AMTN group presented more occluded dentinal tubules compared to PLA and FLU. AMTN and SBU had the lowest values of opened dentin tubules. Results showed a negative correlation between the analyses. Conclusion: The SBU and AMTN solution were more effective in reducing dentin permeability by occluding dentin tubules. Clinical relevance: All materials reduced permeability after challenge, except fluoride varnish.en
dc.description.affiliationDepartment of Preventive and Restorative Dentistry School of Dentistry São Paulo State University (UNESP), CEP
dc.description.affiliationVitreous Materials Laboratory Department of Materials Engineering Federal University of São Carlos
dc.description.affiliationFaculty of Dentistry and Institute of Biomedical Engineering University of Toronto
dc.description.affiliationDepartment of Diagnosis and Surgery Division of Periodontics School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Preventive and Restorative Dentistry School of Dentistry São Paulo State University (UNESP), CEP
dc.description.affiliationUnespDepartment of Diagnosis and Surgery Division of Periodontics School of Dentistry São Paulo State University (UNESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 2020/07625-0
dc.description.sponsorshipIdCAPES: 88887.310463/2018-00
dc.format.extent1265-1276
dc.identifierhttp://dx.doi.org/10.1007/s00784-022-04760-y
dc.identifier.citationClinical Oral Investigations, v. 27, n. 3, p. 1265-1276, 2023.
dc.identifier.doi10.1007/s00784-022-04760-y
dc.identifier.issn1436-3771
dc.identifier.issn1432-6981
dc.identifier.scopus2-s2.0-85140930694
dc.identifier.urihttp://hdl.handle.net/11449/249319
dc.language.isoeng
dc.relation.ispartofClinical Oral Investigations
dc.sourceScopus
dc.subjectDentin desensitizer
dc.subjectDentin hypersensitivity
dc.subjectDentin permeability
dc.subjectDentinal tubule occlusion
dc.titleIn vitro dentin permeability and tubule occlusion of experimental in-office desensitizing materialsen
dc.typeArtigo
unesp.author.orcid0000-0001-7689-4969[1]
unesp.author.orcid0000-0003-4739-2075[2]
unesp.author.orcid0000-0003-2222-2424[3]
unesp.author.orcid0000-0002-8159-4853[4]
unesp.author.orcid0000-0002-0291-6034[5]
unesp.author.orcid0000-0002-5280-978X[6]
unesp.author.orcid0000-0003-3026-8369[7]
unesp.author.orcid0000-0002-3418-0498[8]

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