Plasma concentrations of buprenorphine after epidural administration in conscious cats

dc.contributor.authorDuke-Novakovski, Tanya
dc.contributor.authorClark, Christopher R.
dc.contributor.authorAmbros, Barbara
dc.contributor.authorGilbert, Peter
dc.contributor.authorSteagall, Paulo V. M. [UNESP]
dc.contributor.institutionUniv Saskatchewan
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:32:03Z
dc.date.available2014-05-20T15:32:03Z
dc.date.issued2011-06-01
dc.description.abstractBuprenorphine plasma concentrations were measured after administering buprenorphine (20 mu g/kg) into the lumbosacral epidural space of conscious cats chronically instrumented with an epidural catheter. Blood was collected from a jugular vein before injection and 15, 30, 45 and 60 min and 2, 3, 4, 5, 6, 8, 12 and 24 h after administration. Plasma buprenorphine concentrations were measured using ELISA. Background concentration (before injection) was 1.27 +/- 0.27 ng/mL (mean +/- SD). Including background concentration, the mean peak plasma concentration was obtained 15 min after injection (5.82 +/- 3.75 ng/mL), and ranged from 3.79 to 2.20 ng/mL (30 min-3 h), remaining between 1.93 and 1.77 ng/mL (412 h), and declined to 1.40 +/- 0.62 ng/mL at 24 h. Elimination half-life was 58.8 +/- 40.2 min and clearance 56.7 +/- 21.5 mL/min. Results indicate early rapid systemic uptake of buprenorphine from epidural administration with plasma concentrations similar to using buccal or IM routes by 15 min postinjection. (C) 2010 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Saskatchewan, Western Coll Vet Med, Dept Small Anim Clin Sci, Saskatoon, SK S7N 0W0, Canada
dc.description.affiliationUniv Saskatchewan, Western Coll Vet Med, Dept Large Anim Clin Sci, Saskatoon, SK S7N 0W0, Canada
dc.description.affiliationSão Paulo State Univ, Dept Vet Surg & Anesthesiol, Sch Vet Med, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Dept Vet Surg & Anesthesiol, Sch Vet Med, São Paulo, Brazil
dc.description.sponsorshipCompanion Animal Health Fund
dc.format.extent480-483
dc.identifierhttp://dx.doi.org/10.1016/j.rvsc.2010.07.010
dc.identifier.citationResearch In Veterinary Science. Oxford: Elsevier B.V., v. 90, n. 3, p. 480-483, 2011.
dc.identifier.doi10.1016/j.rvsc.2010.07.010
dc.identifier.issn0034-5288
dc.identifier.urihttp://hdl.handle.net/11449/41054
dc.identifier.wosWOS:000291085200021
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofResearch in Veterinary Science
dc.relation.ispartofjcr1.616
dc.relation.ispartofsjr0,593
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectBuprenorphineen
dc.subjectCaten
dc.subjectEpiduralen
dc.subjectPlasma concentrationen
dc.titlePlasma concentrations of buprenorphine after epidural administration in conscious catsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.

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