LIPID NANOSTRUCTURED CARRIERS SYSTEMS FOR IVERMECTIN AND METHOPRENE AIMING PARASITE CONTROL

dc.contributor.authorCola, Diego Faria [UNESP]
dc.contributor.authorPasquoto, Tatiane
dc.contributor.authorGuilger, Mariana
dc.contributor.authorLima, Renata de
dc.contributor.authorGoncalves da Silva, Camila Morais
dc.contributor.authorFraceto, Leonardo Fernandes [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Sorocaba
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2018-11-26T17:13:53Z
dc.date.available2018-11-26T17:13:53Z
dc.date.issued2016-11-01
dc.description.abstractThe study of characteristics of nanoscale structures and applications now has great interest of researchers from different areas. In this regard, lipid carriers can improve the bioavailability of drugs and the reduction of possible toxicological effects. Thus, the development of nanostructured systems for the agricultural sector, aimed at combating parasites may reduce extensive damage caused to livestock producers and animal health. This study aimed to prepare and characterize lipid carrier systems, such as Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC), as well as evaluate the potential of cyto and genotoxicity of these systems in order to improve and produce alternatives to the use targeting these compounds in veterinary applications. Lipid nanoparticles had become spherical with an average size of 250 nm and remained stable over 120 days. The encapsulation efficiency was greater than 99% for both drugs and release tests showed a strong interaction between drugs and nanoparticles. Cyto- and genotoxicity tests show that nanoparticles made possible changes in cellular viability of the tested cells. Thus, the results showed that the nanoparticles had good colloidal characteristics without changes in its characteristics, enabling the development of carrier systems for these drugs, aiming veterinary applications.en
dc.description.affiliationUniv Estadual Paulista, Dept Engn Ambiental, Ave Tres marco 511, BR-18087180 Sorocaba, SP, Brazil
dc.description.affiliationUniv Sorocaba, Dept Biotecnol, BR-18023000 Sorocaba, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Inst Biol, Dept Bioquim, Cidade Univ Zeferino Vaz, BR-13087970 Campinas, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Engn Ambiental, Ave Tres marco 511, BR-18087180 Sorocaba, SP, Brazil
dc.format.extent1034-1043
dc.identifierhttp://dx.doi.org/10.21577/0100-4042.20160123
dc.identifier.citationQuimica Nova. Sao Paulo: Soc Brasileira Quimica, v. 39, n. 9, p. 1034-1043, 2016.
dc.identifier.doi10.21577/0100-4042.20160123
dc.identifier.fileS0100-40422016000901034.pdf
dc.identifier.issn0100-4042
dc.identifier.scieloS0100-40422016000901034
dc.identifier.urihttp://hdl.handle.net/11449/162258
dc.identifier.wosWOS:000390207600002
dc.language.isopor
dc.publisherSoc Brasileira Quimica
dc.relation.ispartofQuimica Nova
dc.relation.ispartofsjr0,255
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectlipid nanocarriers
dc.subjectparasites
dc.subjectveterinary
dc.subjectgenotoxicity
dc.subjectcytotoxicity
dc.titleLIPID NANOSTRUCTURED CARRIERS SYSTEMS FOR IVERMECTIN AND METHOPRENE AIMING PARASITE CONTROLen
dc.typeArtigo
dcterms.rightsHolderSoc Brasileira Quimica

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