Gastrointestinal Motility, Mucosal Mast Cell, and Intestinal Histology in Rats: Effect of Prednisone

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dc.contributor.authorDe Lima, Maysa Bruno
dc.contributor.authorGama, Loyane Almeida [UNESP]
dc.contributor.authorHauschildt, Andrieli Taise
dc.contributor.authorDall'Agnol, Denize Jussara Rupolo [UNESP]
dc.contributor.authorCorá, Luciana Aparecida
dc.contributor.authorAmerico, Madileine Francely
dc.contributor.institutionUFMT
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUNCISAL
dc.date.accessioned2018-12-11T16:49:56Z
dc.date.available2018-12-11T16:49:56Z
dc.date.issued2017-01-01
dc.description.abstractOur aim was to verify the effects of prednisone related to gastrointestinal motility, intestinal histology, and mucosal mast cells in rats. Two-month-old male Wistar rats were randomly assigned to control group (vehicle) animals receiving saline 0.9% (n=7) or treated orally with 0.625 mg/kg/day of prednisone (n=7) or 2.5 mg/kg/day of prednisone (n=7) during 15 days. Mast cells and other histologic analyses were performed in order to correlate to gastric emptying, cecum arrival, and small intestine transit evaluated by Alternating Current Biosusceptometry. Results showed that prednisone in adult rats increased the frequency of gastric contractions, hastened gastric emptying, slowed small intestinal transit, and reduced mucosal mast cells. Histologically, the treatment with both doses of prednisone decreased villus height, whereas longitudinal and circular muscles and crypt depth were not affected. These findings indicate an impairment of intestinal absorption which may be linked to several GI dysfunctions and symptoms. The relationship between gastrointestinal motor disorders and cellular immunity needs to be clarified in experimental studies since prednisone is one of the most prescribed glucocorticoids worldwide.en
dc.description.affiliationFederal University of Mato Grosso UFMT
dc.description.affiliationSão Paulo State University UNESP
dc.description.affiliationAlagoas State University of Health Sciences UNCISAL
dc.description.affiliationUnespSão Paulo State University UNESP
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.identifierhttp://dx.doi.org/10.1155/2017/4637621
dc.identifier.citationBioMed Research International, v. 2017.
dc.identifier.doi10.1155/2017/4637621
dc.identifier.file2-s2.0-85030771488.pdf
dc.identifier.issn2314-6141
dc.identifier.issn2314-6133
dc.identifier.scopus2-s2.0-85030771488
dc.identifier.urihttp://hdl.handle.net/11449/170250
dc.language.isoeng
dc.relation.ispartofBioMed Research International
dc.relation.ispartofsjr0,935
dc.relation.ispartofsjr0,935
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.titleGastrointestinal Motility, Mucosal Mast Cell, and Intestinal Histology in Rats: Effect of Prednisoneen
dc.typeArtigo
unesp.author.orcid0000-0001-8242-3653[5]

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