Chronic fluoxetine treatment alters cardiovascular functions in unanesthetized rats

dc.contributor.authorCrestani, Carlos Cesar [UNESP]
dc.contributor.authorTavares, Rodrigo F.
dc.contributor.authorGuimaraes, Franscisco S.
dc.contributor.authorCorrea, Fernando M. A.
dc.contributor.authorJoca, Samia R. L.
dc.contributor.authorResstel, Leonardo B. M.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:25:36Z
dc.date.available2014-05-20T13:25:36Z
dc.date.issued2011-11-30
dc.description.abstractIn the present study, we investigated the effects induced by fluoxetine treatment (10 mg/kg) for either 1 or 21 consecutive days on arterial pressure and heart rate basal levels, baroreflex activity, hemodynamic responses to vasoactive agents and cardiovascular responses to acute restraint stress. Mild hypertension was observed after 21 days of treatment, but not after administration for 1 day. Moreover, chronic treatment affected the baroreflex control of heart rate, which was characterized by a reduced reflex tachycardia and an enhanced bradycardiac baroreflex response. The pressor responses to systemic administration of the selective alpha(1)-adrenoceptor agonist phenylephrine, as well as the depressor responses to systemic infusion of the nitric oxide donor sodium nitroprusside, were reduced after chronic fluoxetine treatment. Fluoxetine treatment for 21 days reduced both the pressor and tachycardiac responses evoked by acute restraint stress. In conclusion, the results indicate the development of mild hypertension after chronic fluoxetine treatment. This effect was followed by changes in the baroreflex control of heart rate and altered vascular responsiveness to pressor and depressor agents, which may explain, at least in part, the increase in arterial pressure. Chronic fluoxetine treatment also affected cardiovascular responses to restraint stress, thus indicating that fluoxetine may affect cardiovascular adaptation under conditions of stress. (C) 2011 Elsevier B.V. All rights reserved.en
dc.description.affiliationUSP, Sch Pharmaceut Sci Ribeirao Preto, Dept Chem & Phys, BR-14040903 Ribeirao Preto, SP, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, Sch Pharmaceut Sci Araraquara, Dept Nat Act Principles & Toxicol, BR-14801902 São Paulo, Brazil
dc.description.affiliationUSP, Sch Med Ribeirao Preto, Dept Pharmacol, BR-14049900 Ribeirao Preto, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Sch Pharmaceut Sci Araraquara, Dept Nat Act Principles & Toxicol, BR-14801902 São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 09/03187-9
dc.description.sponsorshipIdFAPESP: 09/18372-6
dc.description.sponsorshipIdFAPESP: 10/16192-8
dc.description.sponsorshipIdFAPESP: 11/07332-3
dc.description.sponsorshipIdCNPq: 470042/2009-5
dc.description.sponsorshipIdCNPq: 305996/2008-8
dc.format.extent527-533
dc.identifierhttp://dx.doi.org/10.1016/j.ejphar.2011.09.030
dc.identifier.citationEuropean Journal of Pharmacology. Amsterdam: Elsevier B.V., v. 670, n. 2-3, p. 527-533, 2011.
dc.identifier.doi10.1016/j.ejphar.2011.09.030
dc.identifier.fileWOS000297449000025.pdf
dc.identifier.issn0014-2999
dc.identifier.lattes1117432571971568
dc.identifier.urihttp://hdl.handle.net/11449/8133
dc.identifier.wosWOS:000297449000025
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofEuropean Journal of Pharmacology
dc.relation.ispartofjcr3.040
dc.relation.ispartofsjr1,057
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectChronic fluoxetine treatmenten
dc.subjectHypertensionen
dc.subjectArterial pressureen
dc.subjectHeart rateen
dc.subjectBaroreflexen
dc.subjectPsychological stressen
dc.titleChronic fluoxetine treatment alters cardiovascular functions in unanesthetized ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes1117432571971568[1]
unesp.author.orcid0000-0002-1942-858X[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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