Citocalasinas produzidas por Xylaria sp., um fungo endofítico de Piper aduncum (piperaceae)

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Data

2010-01-01

Autores

Silva, Geraldo H. [UNESP]
Oliveira, Camila M. de [UNESP]
Teles, Helder L. [UNESP]
Bolzani, Vanderlan da Silva [UNESP]
Araújo, Angela Regina [UNESP]
Pfenning, Ludwig H.
Young, Maria Claudia M.
Costa-Neto, Claudio M.
Haddad, Renato
Eberlin, Marcos N.

Título da Revista

ISSN da Revista

Título de Volume

Editor

Sociedade Brasileira de Química

Resumo

A chemical study on the EtOAc extract produced by Xylaria sp., an endophytic fungus from Piper aduncum, resulted in the isolation of a new cytochalasin 1, along with five known 19,20-epoxycytochalasin D (2), C (3), N (4), Q (5), and R (6). The 1-6 were evaluated against the fungi C. cladosporioides and C. sphaerospermum and only 5 showed weak activity. The cytotoxicity in vitro against HeLA and CHO cells lines were investigated and the cytochalasins 2-4, and 6 showed a strong activity against HeLA. The DNAdamaging activity of 1-6 were also investigated against mutant strains of S. cerevisiae.

Descrição

Palavras-chave

Xylaria sp., Piper aduncum, endophytic fungus

Como citar

Química Nova. Sociedade Brasileira de Química, v. 33, n. 10, p. 2038-2041, 2010.