Serum Metalloproteinases 2 and 9 as Predictors of Gait Status, Pressure Ulcer and Mortality after Hip Fracture

dc.contributor.authorGumieiro, David N. [UNESP]
dc.contributor.authorRafacho, Bruna P. M. [UNESP]
dc.contributor.authorGonçalves, Andrea F. [UNESP]
dc.contributor.authorSantos, Priscila P. [UNESP]
dc.contributor.authorGaiolla, Paula Schmidt Azevedo [UNESP]
dc.contributor.authorZornoff, Leonardo Antonio Mamede [UNESP]
dc.contributor.authorPereira, Gilberto José Cação [UNESP]
dc.contributor.authorMatsubara, Luiz Shiguero [UNESP]
dc.contributor.authorPaiva, Sergio Alberto Rupp de [UNESP]
dc.contributor.authorMinicucci, Marcos Ferreira [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:28:31Z
dc.date.available2014-05-27T11:28:31Z
dc.date.issued2013-02-20
dc.description.abstractIntroduction: The aim of this study is to evaluate the serum activity of metalloproteinases (MMPs) -2 and -9 as predictors of pressure ulcer (PU), gait status and mortality 6 months after hip fracture. Methods: Eighty-seven patients over the age of 65 admitted to the orthopedic unit from January to December 2010 with hip fracture were prospectively evaluated. Upon admission, patient demographic information, including age, gender and concomitant diseases, was recorded. Blood samples were taken for analysis of MMP -2 and -9 activity by gel zymography and for biochemical examination within the first 72 hours of the patient's admission, after clinical stabilization. The fracture pattern (neck, trochanteric or subtrochanteric), time from admission to surgery, surgery duration and length of hospital stay were also recorded. Results: Two patients were excluded due to the presence of pathological fractures (related to cancer), and three patients were excluded due to the presence of PU before admission. Eighty-two patients, with a mean age of 80.4 ± 7.3 years, were included in the analysis. Among these patients, 75.6% were female, 59.8% had PU, and 13.4% died 6 months after hip fracture. All patients underwent hip fracture repair. In a univariate analysis, there were no differences in serum MMP activity between hip fracture patients with or without PU. In addition, the multiple logistic regression analysis models, which were adjusted by age, gender, length of hospital stay and C-reactive protein, showed that the pro-MMP-9 complexed with neutrophil gelatinase-associated lipocalin form (130 kDa) was associated with gait status recovery 6 months after hip fracture. Conclusions: In conclusion, serum pro-MMP-9 is a predictor of gait status recovery 6 months after hip fracture. © 2013 Gumieiro et al.en
dc.description.affiliationSurgery and Orthopedic Department Botucatu Medical School Universidade Estadual Paulista (UNESP), Botucatu
dc.description.affiliationInternal Medicine Department Botucatu Medical School Universidade Estadual Paulista (UNESP), Botucatu
dc.description.affiliationUnespSurgery and Orthopedic Department Botucatu Medical School Universidade Estadual Paulista (UNESP), Botucatu
dc.description.affiliationUnespInternal Medicine Department Botucatu Medical School Universidade Estadual Paulista (UNESP), Botucatu
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0057424
dc.identifier.citationPLoS ONE, v. 8, n. 2, 2013.
dc.identifier.doi10.1371/journal.pone.0057424
dc.identifier.file2-s2.0-84874230579.pdf
dc.identifier.issn1932-6203
dc.identifier.lattes6309835137998766
dc.identifier.lattes5016839015394547
dc.identifier.lattes1213140801402647
dc.identifier.lattes7438704034471673
dc.identifier.orcid0000-0002-5843-6232
dc.identifier.scopus2-s2.0-84874230579
dc.identifier.urihttp://hdl.handle.net/11449/74619
dc.identifier.wosWOS:000315184200254
dc.language.isoeng
dc.relation.ispartofPLOS ONE
dc.relation.ispartofjcr2.766
dc.relation.ispartofsjr1,164
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectC reactive protein
dc.subjectgelatinase A
dc.subjectgelatinase B
dc.subjectlipocalin
dc.subjectaged
dc.subjectblood sampling
dc.subjectdecubitus
dc.subjectdemography
dc.subjectenzyme activity
dc.subjectenzyme blood level
dc.subjectfemale
dc.subjectfemur intertrochanteric fracture
dc.subjectfemur neck fracture
dc.subjectfemur subtrochanteric fracture
dc.subjectgait
dc.subjecthip fracture
dc.subjecthospitalization
dc.subjecthuman
dc.subjectlength of stay
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmortality
dc.subjectneutrophil
dc.subjectoperation duration
dc.subjectprediction
dc.subjectprospective study
dc.subjectzymography
dc.subjectAcute-Phase Proteins
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectBiological Markers
dc.subjectC-Reactive Protein
dc.subjectFemale
dc.subjectGait
dc.subjectHip Fractures
dc.subjectHumans
dc.subjectLength of Stay
dc.subjectLipocalins
dc.subjectMale
dc.subjectMatrix Metalloproteinase 2
dc.subjectMatrix Metalloproteinase 9
dc.subjectPressure Ulcer
dc.subjectPrognosis
dc.subjectProspective Studies
dc.subjectProtein Binding
dc.subjectProto-Oncogene Proteins
dc.subjectRecovery of Function
dc.subjectRegression Analysis
dc.subjectSurvival Analysis
dc.subjectTreatment Outcome
dc.titleSerum Metalloproteinases 2 and 9 as Predictors of Gait Status, Pressure Ulcer and Mortality after Hip Fractureen
dc.typeArtigo
dcterms.licensehttp://www.plos.org/open-access/
unesp.author.lattes5016839015394547[6]
unesp.author.lattes6309835137998766
unesp.author.lattes1213140801402647[5]
unesp.author.lattes7438704034471673
unesp.author.orcid0000-0002-5980-4367[10]
unesp.author.orcid0000-0003-4412-1990[9]
unesp.author.orcid0000-0001-8825-6980[2]
unesp.author.orcid0000-0002-5843-6232[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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