Chemoselective condensationof beta-naphthol, dimethyl malonate, andaromatic aldehydes promoted by niobium pentachloride
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Undergraduate course
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Publisher
Taylor &francis Inc
Type
Article
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Abstract
A multicomponent reaction of β-naphthol, dimethyl malonate, and aromatic aldehydes in the presence of NbCl5 as promoter is described. Under similar conditions, aromatic aldehydes with different substituents exhibited different behaviors than β-naphthol and dimethyl malonate. In these MCRs, 4-aryl-3,4-dihydrobenzo[f]coumarins are obtained as the major products (41–93%) and 14-aryl-14H-dibenzo[a,j]xanthenes as the minor products (1–38%).
Description
Keywords
Chemoselective, Niobium pentachloride, Multicomponent reactions, Lewis acid, 4-Aryl-3, 4 dihydrobenzo[f]coumarins, 4-Aryl-3,4-dihydrobenzo[f]coumarins
Language
English
Citation
Synthetic Communications, v. 45, n. 9, p. 1114-1126, 2015.
