Publicação:
Analysis of Interictal Epileptiform Discharges in Mesial Temporal Lobe Epilepsy Using Quantitative EEG and Neuroimaging

dc.contributor.authorFujisao, Elaine Keiko [UNESP]
dc.contributor.authorAlves, Karen Fernanda [UNESP]
dc.contributor.authorRezende, Thais O. P. [UNESP]
dc.contributor.authorBetting, Luiz Eduardo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2021-06-25T10:46:44Z
dc.date.available2021-06-25T10:46:44Z
dc.date.issued2020-11-26
dc.description.abstractObjective: Investigate areas of correlation between gray matter volumes by MRI and interictal EEG source maps in subtypes of mesial temporal lobe epilepsy (MTLE). Method: 71 patients and 36 controls underwent 3T MRI and and routine EEG was performed. Voxel-based morphometry (VBM) was used for gray matter analysis and analysis of interictal discharge sources for quantitative EEG. Voxel-wise correlation analysis was conducted between the gray matter and EEG source maps in MTLE subtypes. Results: The claustrum was the main structure involved in the individual source analysis. Twelve patients had bilateral HA, VBM showed bilateral hippocampal. Twenty-one patients had right HA, VBM showed right hippocampal and thalamic atrophy and negatively correlated involving the right inferior frontal gyrus and insula. Twenty-two patients had left HA, VBM showed left hippocampal atrophy and negatively correlated involving the left temporal lobe and insula. Sixteen patients had MTLE without HA, VBM showed middle cingulate gyrus atrophy and were negatively correlated involving extra-temporal regions, the main one located in postcentral gyrus. Conclusions: Negative correlations between gray matter volumes and EEG source imaging. Neuroanatomical generators of interictal discharges are heterogeneous and vary according to MTLE subtype. Significance: These findings suggest different pathophysiological mechanisms among patients with different subtypes of MTLE.en
dc.description.affiliationDepartamento de Neurologia Psiquiatria e Psicologia Faculdade de Medicina de Botucatu UNESP - Universidade Estadual Paulista
dc.description.affiliationUnespDepartamento de Neurologia Psiquiatria e Psicologia Faculdade de Medicina de Botucatu UNESP - Universidade Estadual Paulista
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.identifierhttp://dx.doi.org/10.3389/fneur.2020.569943
dc.identifier.citationFrontiers in Neurology, v. 11.
dc.identifier.doi10.3389/fneur.2020.569943
dc.identifier.issn1664-2295
dc.identifier.scopus2-s2.0-85097489158
dc.identifier.urihttp://hdl.handle.net/11449/206959
dc.language.isoeng
dc.relation.ispartofFrontiers in Neurology
dc.sourceScopus
dc.subjecteletroencepalogram
dc.subjecthippocampal atrophy
dc.subjectmagnetic ressonance imaging
dc.subjectmesial temporal lobe epilepsy
dc.subjectquantitative EEG
dc.subjectquantitative MR analysis
dc.titleAnalysis of Interictal Epileptiform Discharges in Mesial Temporal Lobe Epilepsy Using Quantitative EEG and Neuroimagingen
dc.typeArtigo
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentNeurologia, Psicologia e Psiquiatria - FMBpt

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