Chrysophanol: A natural anthraquinone with multifaceted biotherapeutic potential

dc.contributor.authorYusuf, Mohd Aslam
dc.contributor.authorSingh, Brahma N.
dc.contributor.authorSudheer, Surya
dc.contributor.authorKharwar, Ravindra N.
dc.contributor.authorSiddiqui, Saba
dc.contributor.authorAbdel-Azeem, Ahmed M.
dc.contributor.authorFraceto, Leonardo Fernandes [UNESP]
dc.contributor.authorDashora, Kavya
dc.contributor.authorGupta, Vijai K.
dc.contributor.institutionIntegral University
dc.contributor.institutionCSIR-National Botanical Research Institute
dc.contributor.institutionTallinn University of Technology
dc.contributor.institutionBanaras Hindu University
dc.contributor.institutionUniversity of Suez Canal
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionIndian Institute of Technology Delhi
dc.description.abstractChrysophanol is a unique anthraquinone having broad-spectrum therapeutic potential along with ecological importance. It is the first polyketide that has been reported to be biosynthesized in an organism-specific manner. The traditional Chinese and Korean medicinal systems provide evidence of the beneficial effects of chrysophanol on human health. The global distribution of chrysophanol encountered in two domains of life (bacteria and eukaryota) has motivated researchers to critically evaluate the properties of this compound. A plethora of literature is available on the pharmacological properties of chrysophanol, which include anticancer, hepatoprotective, neuroprotective, anti-inflammatory, antiulcer, and antimicrobial activities. However, the pharmacokinetics and toxicity studies on chrysophanol demand further investigations for it to be used as a drug. This is the first comprehensive review on the natural sources, biosynthetic pathways, and pharmacology of chrysophanol. Here we reviewed recent advancements made on the pharmacokinetics of the chrysophanol. Additionally, we have highlighted the knowledge gaps of its mechanism of action against diseases and toxicity aspects.en
dc.description.affiliationDepartment of Biosciences Integral University
dc.description.affiliationHerbal Nanobiotechnology Lab Pharmacology Division CSIR-National Botanical Research Institute
dc.description.affiliationDepartment of Bioengineering Integral University
dc.description.affiliationDepartment of Chemistry and Biotechnology ERA Chair of Green Chemistry Tallinn University of Technology
dc.description.affiliationCentre of Advanced Study in Botany Institute of Science Banaras Hindu University
dc.description.affiliationIntegral Institute of Agricultural Science and Technology (IIAST) Integral University
dc.description.affiliationBotany Department Faculty of Science University of Suez Canal
dc.description.affiliationInstitute of Science and Technology of Sorocaba São Paulo State University–Unesp
dc.description.affiliationCentre for Rural Development and Technology Indian Institute of Technology Delhi, Hauz Khas
dc.description.affiliationUnespInstitute of Science and Technology of Sorocaba São Paulo State University–Unesp
dc.description.sponsorshipSeventh Framework Programme
dc.description.sponsorshipSchizophrenia Research Fund
dc.description.sponsorshipIdSeventh Framework Programme: 621364
dc.description.sponsorshipIdSchizophrenia Research Fund: OLP-0106
dc.identifier.citationBiomolecules, v. 9, n. 2, 2019.
dc.rights.accessRightsAcesso aberto
dc.titleChrysophanol: A natural anthraquinone with multifaceted biotherapeutic potentialen