Favourable effects of Bacillus subtilis and Bacillus licheniformis on experimental periodontitis in rats

dc.contributor.authorMessora, Michel R.
dc.contributor.authorPereira, Luciano J.
dc.contributor.authorFoureaux, Renata
dc.contributor.authorOliveira, Luiz F.F.
dc.contributor.authorSordi, Caio G.
dc.contributor.authorAlves, Ana J.N.
dc.contributor.authorNapimoga, Marcelo H.
dc.contributor.authorNagata, Maria J.H. [UNESP]
dc.contributor.authorErvolino, Edilson [UNESP]
dc.contributor.authorFurlaneto, Flávia A.C.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionFederal University of Lavras
dc.contributor.institutionSao Leopoldo Mandic
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:01:31Z
dc.date.available2018-12-11T17:01:31Z
dc.date.issued2016-06-01
dc.description.abstractObjectives The purposes of this study were to evaluate, in rats: i) the effects of Bacillus species on the development of experimental periodontitis (EP) via microtomographic, immunological and hematological assays (Experiment 1 - E1); ii) the effects of Bacillus species as adjuncts to scaling and root planing (SRP) for the treatment of EP via histomorphometric and immunohistochemical analyses (Experiment 2 - E2). Methods In E1, 24 rats were divided into groups C1 (control), PROB1, EP1 and EP-PROB1. In groups with EP, the mandibular first molar of each animal received a ligature for 14 days. In groups PROB1, animals received Bacillus species for 44 days, starting 30 days before EP induction in Group EP-PROB1. In E2, 24 rats were assigned to groups C2 (control), PROB2, EP-SRP2 and EP-SRP-PROB2. In groups with SRP, EP was induced as described in E1. The ligatures were removed after 14 days and SRP was performed. In groups PROB2, animals received Bacillus species for 15 days, starting after SRP in Group EP-SRP-PROB2. Results In E1, Group EP1 presented bone loss (BL) and eosinophil numbers greater than Group EP-PROB1 (P < 0.05). In Group EP-PROB1, the receptor activator of nuclear factor-kB ligand (RANKL)/osteoprotegerin (OPG) ratio was similar to that of groups without EP. In E2, Group EP-SRP-PROB2 presented fewer TRAP-positive osteoclasts, lower immunolabeling pattern for a proinflammatory cytokine and decreased BL and attachment loss than Group EP-SRP2 (P < 0.05). Conclusions Bacillus species supplementation provided a protective effect against BL and enhanced the effects of SRP in the treatment of EP in rats.en
dc.description.affiliationDepartment of Oral and Maxillofacial Surgery and Periodontology School of Dentistry of Ribeirao Preto University of Sao Paulo - USP, Av. Café
dc.description.affiliationPhysiology and Pharmacology Department Federal University of Lavras, Av. Doutor Sylvio Menicucci, 1001
dc.description.affiliationLaboratory of Immunology and Molecular Biology Sao Leopoldo Mandic, Street Dr. José Rocha Junqueira, 13
dc.description.affiliationDepartment of Surgery Integrated Clinic Dental School of Aracatuba UNESP-Univ Estadual Paulista, Street José Bonifácio, 1193
dc.description.affiliationDepartment of Basic Sciences Division of Histology Dental School of Aracatuba UNESP-Univ Estadual Paulista, Rodovia Marechal Rondon, km 527
dc.description.affiliationUnespDepartment of Surgery Integrated Clinic Dental School of Aracatuba UNESP-Univ Estadual Paulista, Street José Bonifácio, 1193
dc.description.affiliationUnespDepartment of Basic Sciences Division of Histology Dental School of Aracatuba UNESP-Univ Estadual Paulista, Rodovia Marechal Rondon, km 527
dc.format.extent108-119
dc.identifierhttp://dx.doi.org/10.1016/j.archoralbio.2016.02.014
dc.identifier.citationArchives of Oral Biology, v. 66, p. 108-119.
dc.identifier.doi10.1016/j.archoralbio.2016.02.014
dc.identifier.file2-s2.0-84959544483.pdf
dc.identifier.issn1879-1506
dc.identifier.issn0003-9969
dc.identifier.lattes4408095517346846
dc.identifier.orcid0000-0003-4859-0583
dc.identifier.scopus2-s2.0-84959544483
dc.identifier.urihttp://hdl.handle.net/11449/172631
dc.language.isoeng
dc.relation.ispartofArchives of Oral Biology
dc.relation.ispartofsjr0,752
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectPeriodontitis
dc.subjectProbiotics
dc.subjectRats
dc.subjectRoot planing
dc.titleFavourable effects of Bacillus subtilis and Bacillus licheniformis on experimental periodontitis in ratsen
dc.typeArtigo
unesp.author.lattes4408095517346846[9]
unesp.author.orcid0000-0003-4859-0583[9]

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