Cardiac baroreflex is already blunted in eight weeks old spontaneously hypertensive rats

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dc.contributor.authorCisternas, José R
dc.contributor.authorValenti, Vitor Engrácia [UNESP]
dc.contributor.authorAlves, Thales B
dc.contributor.authorFerreira, Celso
dc.contributor.authorPetenusso, Márcio
dc.contributor.authorBreda, João R
dc.contributor.authorPires, Adilson C
dc.contributor.authorTassi, Nadir [UNESP]
dc.contributor.authorAbreu, Luiz Carlos de [UNESP]
dc.contributor.institutionSchool of Medicine of ABC
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:24:39Z
dc.date.available2014-05-27T11:24:39Z
dc.date.issued2010-03-11
dc.description.abstractBackground. The literature did not evidence yet with which age spontaneously hypertensive rats (SHR) start to present baroreflex reduction. We endeavored to evaluate the baroreflex function in eight-week-old SHR. Methods. Male Wistar Kyoto (WKY) normotensive rats and SHR aged eight weeks were studied. Baroreflex was calculated as the variation of heart rate (HR) divided by the mean arterial pressure (MAP) variation (HR/MAP) tested with a depressor dose of sodium nitroprusside (SNP, 50 g/kg) and with a pressor dose of phenylephrine (PHE, 8 g/kg) in the right femoral venous approach through an inserted cannula in the animals. Significant differences for p < 0.05. Results. Baseline MAP (p < 0.0001) and HR (p = 0.0028) was higher in SHR. Bradycardic peak was attenuated in SHR (p < 0.0001), baroreflex gain tested with PHE was also reduced in the SHR group (p = 0.0012). PHE-induced increase in MAP was increased in WKY compared to SHR (p = 0.039). Bradycardic reflex responses to intravenous PHE was decreased in SHR (p < 0.0001). Conclusion. Eight weeks old SHR already presents impairment of the parasympathetic component of baroreflex. © 2010 Cisternas et al; licensee BioMed Central Ltd.en
dc.description.affiliationDepartment of Morphology and Physiology School of Medicine of ABC, Av. Príncipe de Gales, 821, Santo André 09060-650
dc.description.affiliationDepartment of Clinical Medicine Cardiology Division School of Medicine of ABC, Av. Príncipe de Gales, 821, Santo André 09060-650
dc.description.affiliationDepartment of Medicine Cardiology Division Federal University of São Paulo (UNIFESP), Rua Napoleo de Barros, 715, Térreo, São Paulo 04039-032
dc.description.affiliationDepartment of Physiology Federal University of São Paulo (UNIFESP), Rua Napoleo de Barros, 715, Térreo, São Paulo 04039-032
dc.description.affiliationCardiovascular Surgery Division School of Medicine of ABC, Av. Príncipe de Gales, 821, Santo André 09060-650
dc.description.affiliationSpeech Pathology and Audiology Department Faculty of Philosophy and Sciences Paulista State University (UNESP), Av. Hygino Muzzi Filho, 737, Marília 17525-900
dc.description.affiliationUnespSpeech Pathology and Audiology Department Faculty of Philosophy and Sciences Paulista State University (UNESP), Av. Hygino Muzzi Filho, 737, Marília 17525-900
dc.identifierhttp://dx.doi.org/10.1186/1755-7682-3-2
dc.identifier.citationInternational Archives of Medicine, v. 3, n. 1, 2010.
dc.identifier.doi10.1186/1755-7682-3-2
dc.identifier.file2-s2.0-77649320772.pdf
dc.identifier.issn1755-7682
dc.identifier.scopus2-s2.0-77649320772
dc.identifier.urihttp://hdl.handle.net/11449/71606
dc.language.isoeng
dc.relation.ispartofInternational Archives of Medicine
dc.relation.ispartofsjr0,237
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectnitroprusside sodium
dc.subjectphenylephrine
dc.subjectaged
dc.subjectanimal experiment
dc.subjectbradycardia
dc.subjectcannulation
dc.subjectcardiac baroreflex
dc.subjectclinical evaluation
dc.subjectcontrolled study
dc.subjectfemoral vein
dc.subjectheart rate
dc.subjectmale
dc.subjectmean arterial pressure
dc.subjectnonhuman
dc.subjectpressoreceptor reflex
dc.subjectrat
dc.subjectspontaneously hypertensive rat
dc.subjectWistar Kyoto rat
dc.titleCardiac baroreflex is already blunted in eight weeks old spontaneously hypertensive ratsen
dc.typeArtigo
dcterms.licensehttp://www.biomedcentral.com/about/license
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Filosofia e Ciências, Maríliapt
unesp.departmentFonoaudiologia - FFCpt

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