Cardiac baroreflex is already blunted in eight weeks old spontaneously hypertensive rats
dc.contributor.author | Cisternas, José R | |
dc.contributor.author | Valenti, Vitor Engrácia [UNESP] | |
dc.contributor.author | Alves, Thales B | |
dc.contributor.author | Ferreira, Celso | |
dc.contributor.author | Petenusso, Márcio | |
dc.contributor.author | Breda, João R | |
dc.contributor.author | Pires, Adilson C | |
dc.contributor.author | Tassi, Nadir [UNESP] | |
dc.contributor.author | Abreu, Luiz Carlos de [UNESP] | |
dc.contributor.institution | School of Medicine of ABC | |
dc.contributor.institution | Universidade de São Paulo (USP) | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2014-05-27T11:24:39Z | |
dc.date.available | 2014-05-27T11:24:39Z | |
dc.date.issued | 2010-03-11 | |
dc.description.abstract | Background. The literature did not evidence yet with which age spontaneously hypertensive rats (SHR) start to present baroreflex reduction. We endeavored to evaluate the baroreflex function in eight-week-old SHR. Methods. Male Wistar Kyoto (WKY) normotensive rats and SHR aged eight weeks were studied. Baroreflex was calculated as the variation of heart rate (HR) divided by the mean arterial pressure (MAP) variation (HR/MAP) tested with a depressor dose of sodium nitroprusside (SNP, 50 g/kg) and with a pressor dose of phenylephrine (PHE, 8 g/kg) in the right femoral venous approach through an inserted cannula in the animals. Significant differences for p < 0.05. Results. Baseline MAP (p < 0.0001) and HR (p = 0.0028) was higher in SHR. Bradycardic peak was attenuated in SHR (p < 0.0001), baroreflex gain tested with PHE was also reduced in the SHR group (p = 0.0012). PHE-induced increase in MAP was increased in WKY compared to SHR (p = 0.039). Bradycardic reflex responses to intravenous PHE was decreased in SHR (p < 0.0001). Conclusion. Eight weeks old SHR already presents impairment of the parasympathetic component of baroreflex. © 2010 Cisternas et al; licensee BioMed Central Ltd. | en |
dc.description.affiliation | Department of Morphology and Physiology School of Medicine of ABC, Av. Príncipe de Gales, 821, Santo André 09060-650 | |
dc.description.affiliation | Department of Clinical Medicine Cardiology Division School of Medicine of ABC, Av. Príncipe de Gales, 821, Santo André 09060-650 | |
dc.description.affiliation | Department of Medicine Cardiology Division Federal University of São Paulo (UNIFESP), Rua Napoleo de Barros, 715, Térreo, São Paulo 04039-032 | |
dc.description.affiliation | Department of Physiology Federal University of São Paulo (UNIFESP), Rua Napoleo de Barros, 715, Térreo, São Paulo 04039-032 | |
dc.description.affiliation | Cardiovascular Surgery Division School of Medicine of ABC, Av. Príncipe de Gales, 821, Santo André 09060-650 | |
dc.description.affiliation | Speech Pathology and Audiology Department Faculty of Philosophy and Sciences Paulista State University (UNESP), Av. Hygino Muzzi Filho, 737, Marília 17525-900 | |
dc.description.affiliationUnesp | Speech Pathology and Audiology Department Faculty of Philosophy and Sciences Paulista State University (UNESP), Av. Hygino Muzzi Filho, 737, Marília 17525-900 | |
dc.identifier | http://dx.doi.org/10.1186/1755-7682-3-2 | |
dc.identifier.citation | International Archives of Medicine, v. 3, n. 1, 2010. | |
dc.identifier.doi | 10.1186/1755-7682-3-2 | |
dc.identifier.file | 2-s2.0-77649320772.pdf | |
dc.identifier.issn | 1755-7682 | |
dc.identifier.scopus | 2-s2.0-77649320772 | |
dc.identifier.uri | http://hdl.handle.net/11449/71606 | |
dc.language.iso | eng | |
dc.relation.ispartof | International Archives of Medicine | |
dc.relation.ispartofsjr | 0,237 | |
dc.rights.accessRights | Acesso aberto | |
dc.source | Scopus | |
dc.subject | nitroprusside sodium | |
dc.subject | phenylephrine | |
dc.subject | aged | |
dc.subject | animal experiment | |
dc.subject | bradycardia | |
dc.subject | cannulation | |
dc.subject | cardiac baroreflex | |
dc.subject | clinical evaluation | |
dc.subject | controlled study | |
dc.subject | femoral vein | |
dc.subject | heart rate | |
dc.subject | male | |
dc.subject | mean arterial pressure | |
dc.subject | nonhuman | |
dc.subject | pressoreceptor reflex | |
dc.subject | rat | |
dc.subject | spontaneously hypertensive rat | |
dc.subject | Wistar Kyoto rat | |
dc.title | Cardiac baroreflex is already blunted in eight weeks old spontaneously hypertensive rats | en |
dc.type | Artigo | |
dcterms.license | http://www.biomedcentral.com/about/license | |
unesp.campus | Universidade Estadual Paulista (Unesp), Faculdade de Filosofia e Ciências, Marília | pt |
unesp.department | Fonoaudiologia - FFC | pt |
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