Triterpenes and saponins from Rudgea viburnioides


A novel triterpene; viburgenin (1), has been isolated from an extract of the ripe fruit rinds of Rudgea viburnioides, together with the known saponins, arjunglucoside I and trachelosperosides B-1 and E-l, and the triterpenes trachelosperogenin B (2) and arjungenin. Compound 2 was previously obtained as a product from enzymatic hydrolysis, and it is reported for the first time as a natural product. The structure of compound 1 was determined as 2α,3β,19α,23,24-pentahydroxyurs-12-ene by extensive use of 1D and 2D NMR spectroscopic methods. Compound 1 exhibited moderate antifungal activity against Cladosporium cladosporioides.



miconazole, nystatin, saponin, trachelosperogenin b, triterpene, unclassified drug, viburgenin, antifungal activity, bioassay, brazil, cladosporium, drug isolation, fruit, hydrolysis, mass spectrometry, nonhuman, nuclear magnetic resonance spectroscopy, Antifungal Agents, Brazil, Chromatography, Thin Layer, Cladosporium, Magnetic Resonance Spectroscopy, Mass Spectrometry, Microbial Sensitivity Tests, Plants, Medicinal, Saponins, Spectrophotometry, Infrared, Spectrophotometry, Ultraviolet, Triterpenes, Cladosporium cladosporioides, Rudgea, Rudgea viburnioides

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Journal of Natural Products, v. 61, n. 7, p. 936-938, 1998.