Full mouth periodontal debridement with or without adjunctive metronidazole gel in smoking patients with chronic periodontitis: A pilot study

dc.contributor.authorBergamaschi, C. C.
dc.contributor.authorSantamaria, M. P. [UNESP]
dc.contributor.authorBerto, L. A.
dc.contributor.authorCogo-Mueller, K.
dc.contributor.authorMotta, R. H. L.
dc.contributor.authorSalum, E. A.
dc.contributor.authorNociti Junior, F. H.
dc.contributor.authorGoodson, J. M.
dc.contributor.authorGroppo, F. C.
dc.contributor.institutionUniv Sorocaba
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniv Santo Amaro
dc.contributor.institutionSao Leopoldo Mandic Dent Sch
dc.contributor.institutionForsyth Inst
dc.date.accessioned2018-11-26T15:28:31Z
dc.date.available2018-11-26T15:28:31Z
dc.date.issued2016-02-01
dc.description.abstractBackground and ObjectiveThe evidence of effectiveness of metronidazole (Mtz) as an adjunct therapy to periodontal procedure in the treatment of patients with chronic periodontitis is not conclusive. The aim of this study was to compare the effect of Mtz (delivered locally as a gel or systemically as a tablet) as an adjunctive therapy with full mouth periodontal debridement (1h of ultrasonic calculus/plaque removal) in smokers with chronic periodontitis. Material and MethodsThis pilot study involved 30 smokers with at least six teeth with a clinical attachment loss of 5mm and probing pocket depth (PPD) of 5mm. They were randomly assigned into one of three groups (n=10): (i) 3g daily of placebo gel applied topically (using a dental tray with the gel overnight) + periodontal debridement; (ii) 3g daily of a 15% Mtz benzoate gel applied topically (using a dental tray with the gel overnight) + periodontal debridement; and (iii) a daily single dose of 750mg Mtz (Flagyl((R))) + periodontal debridement. Clinical parameters (visible plaque index, gingival bleeding index [GBI], relative attachment level and PPD) and quantitative analysis (by real-time polymerase chain reaction) of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Tannerella forsythia were assessed at baseline and at 1, 3 and 6mo after periodontal debridement. ResultsThere was no statistically significant difference in the average GBI and visible plaque index values at baseline between the groups (p0.05). There was no significant difference between groups in all parameters evaluated (p0.05). Significant reductions in GBI at 3 and 6mo were observed in all groups (p<0.05). Significant reductions in both PPD and relative attachment level at 1, 3 and 6mo were observed in all groups (p<0.05). Significant reductions in bacterial levels at 7 and 30d were observed in all groups (p<0.05). ConclusionAdjunctive use of Mtz (gel or tablet) to periodontal debridement had similar clinical and microbiological improvement compared to treatment with placebo + periodontal debridement in smokers with chronic periodontitis up to 6mo post-treatment. Further studies are necessary to confirm the clinical relevance of these findings.en
dc.description.affiliationUniv Sorocaba, Dept Pharmaceut Sci, BR-18023000 Sorocaba, SP, Brazil
dc.description.affiliationState Univ Sao Paulo, Coll Dent, Div Periodont, Sao Jose Dos Campos, Brazil
dc.description.affiliationUniv Estadual Campinas, Dent Sch Piracicaba, Dept Pharmacol Anesthesiol & Therapeut, Piracicaba, Brazil
dc.description.affiliationUniv Santo Amaro, Dept Dent, Sao Paulo, Brazil
dc.description.affiliationSao Leopoldo Mandic Dent Sch, Dept Pharmacol Anesthesiol & Therapeut, Campinas, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Dent Sch Piracicaba, Dept Prosthodont & Periodontol, Piracicaba, Brazil
dc.description.affiliationForsyth Inst, Dept Clin Res, Boston, MA USA
dc.description.affiliationUnespState Univ Sao Paulo, Coll Dent, Div Periodont, Sao Jose Dos Campos, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 06/01492-0
dc.description.sponsorshipIdFAPESP: 06/0898-9
dc.format.extent50-59
dc.identifierhttp://dx.doi.org/10.1111/jre.12278
dc.identifier.citationJournal Of Periodontal Research. Hoboken: Wiley-blackwell, v. 51, n. 1, p. 50-59, 2016.
dc.identifier.doi10.1111/jre.12278
dc.identifier.issn0022-3484
dc.identifier.urihttp://hdl.handle.net/11449/158659
dc.identifier.wosWOS:000367948400005
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal Of Periodontal Research
dc.relation.ispartofsjr0,927
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectadjunctive periodontal therapy
dc.subjectmetronidazole
dc.subjectperiodontitis
dc.subjectsmoking
dc.titleFull mouth periodontal debridement with or without adjunctive metronidazole gel in smoking patients with chronic periodontitis: A pilot studyen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell

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