Atenção!


O atendimento às questões referentes ao Repositório Institucional será interrompido entre os dias 20 de dezembro de 2024 a 5 de janeiro de 2025.

Pedimos a sua compreensão e aproveitamos para desejar boas festas!

 

Increased peripheral blood TCD4(+) counts and serum SP-D levels in patients with chronic paracoccidioidomycosis, during and after antifungal therapy

dc.contributor.authorVenturini, James [UNESP]
dc.contributor.authorCavalcante, Ricardo Souza [UNESP]
dc.contributor.authorSylvestre, Tatiane Fernanda [UNESP]
dc.contributor.authorSantos, Rodolfo Ferreira dos [UNESP]
dc.contributor.authorMoris, Daniela Vanessa [UNESP]
dc.contributor.authorCarvalho, Lidia Raquel [UNESP]
dc.contributor.authorParreira de Arruda, Maria Sueli [UNESP]
dc.contributor.authorGolim, Marjorie de Assis [UNESP]
dc.contributor.authorMendes, Rinaldo Poncio [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-11-29T01:20:52Z
dc.date.available2018-11-29T01:20:52Z
dc.date.issued2017-11-01
dc.description.abstractBACKGROUND The main clinical forms of paracoccidioidomycosis (PCM) are the acute/subacute form (AF) and the chronic form (CF), and they both display considerable clinical variability. The immune responses of PCM patients, during and after treatment, remain neglected, mainly in the case of CF patients, due to the high prevalence of pulmonary sequelae. OBJECTIVE To evaluate the distribution of whole blood T cell subsets, serum cytokines, and biomarkers of pulmonary fibrosis in PCM patients, according to the clinical form and at different time points, during the antifungal therapy. METHODS Eighty-seven PCM patients, from an endemic area in Brazil, were categorised into groups, according to the clinical form (AF or CF) and the moment of treatment. The peripheral blood T lymphocyte subsets of these patients were analysed using fluorescence-activated cell sorting. The serum levels of cytokines, basic fibroblast growth factor and surfactant protein-D (SP-D) were also analysed. FINDINGS In the CF patients, an expansion of the peripheral blood TCD4(+) cells was observed during the treatment, and this persisted even after two years of antifungal treatment. In addition, these patients showed high serum levels of SP-D. CONCLUSION Our findings highlight the immunological changes CF patients undergo, during and after treatment, possibly due to the hypoxia triggered by pulmonary fibrosis and emphysema.en
dc.description.affiliationUniv Estadual Paulista, Fac Med, Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias, Bauru, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Med, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias, Bauru, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biociencias, Botucatu, SP, Brazil
dc.format.extent748-755
dc.identifierhttp://dx.doi.org/10.1590/0074-02760170046
dc.identifier.citationMemorias Do Instituto Oswaldo Cruz. Rio De Janeiro, Rj: Fundaco Oswaldo Cruz, v. 112, n. 11, p. 748-755, 2017.
dc.identifier.doi10.1590/0074-02760170046
dc.identifier.fileS0074-02762017001100748.pdf
dc.identifier.issn0074-0276
dc.identifier.scieloS0074-02762017001100748
dc.identifier.urihttp://hdl.handle.net/11449/165858
dc.identifier.wosWOS:000414023000003
dc.language.isoeng
dc.publisherFundaco Oswaldo Cruz
dc.relation.ispartofMemorias Do Instituto Oswaldo Cruz
dc.relation.ispartofsjr1,172
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectparacoccidioidomycosis
dc.subjectT-lymphocyte subsets
dc.subjectantifungal agents
dc.subjectpulmonary fibrosis
dc.subjectemphysema
dc.subjectsurfactant protein-D
dc.titleIncreased peripheral blood TCD4(+) counts and serum SP-D levels in patients with chronic paracoccidioidomycosis, during and after antifungal therapyen
dc.typeArtigo
dcterms.rightsHolderFundaco Oswaldo Cruz
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentDoenças Tropicais e Diagnósticos por Imagem - FMBpt

Arquivos

Pacote Original

Agora exibindo 1 - 1 de 1
Carregando...
Imagem de Miniatura
Nome:
S0074-02762017001100748.pdf
Tamanho:
753.41 KB
Formato:
Adobe Portable Document Format