Avaliação da vacinação anti-rábica e da suplementação com probiótico na resposta imune humoral em bovinos
Ferreira, Luciene Aparecida
Pardo, Paulo Eduardo
Frazatti-Gallina, Neuza Maria
Mourao-Fuches, Regina Maria
Ventini, Daniella Cristina
Kronka, Sergio do Nascimento
Arenas, Sandro Eduardo
Lima de Souza Reis, Luis Souza [UNESP]
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Universidade Estadual de Londrina (UEL)
This study evaluated the humoral immune response of a new rabies vaccine developed by the Instituto Butantan (potency of 3.27 UI/ml) in primovaccinated cattle and the effect of probiotic on this response. Thirty-four 15-month old Nelore cattle were randomly divided into 2 groups (17 animals/group). All the animals were vaccinated on day 0 (zero) and then animals in one group received probiotic added to a mineral mixture (GP) while the others were given only the mineral mixture (GC). Blood samples were collected on days 0, 75 and 150 for rabies neutralizing antibodies titers by seroneutralization assay on BHK21 cells (RFFIT). Protective antibody titers (>= 0.5 UI/mL) were found in 82.4% of the animals from GP and in 76.5% of the animals from GC and no statistical difference (p>0.05) between antibody titers in GP and GC was detected on days 75 and 150. It was also observed that in both groups antibody titers was decreased on day 150 (p<0.01). In conclusion, the tested rabies vaccine promotes efficient soroconversion and keeps antibody levels in primovaccinated cattle, but probiotic does not affect the humoral anti-rabies immune response.
Probiotic, humoral immune response, rabies vaccination, antibodies, cattle
Semina-ciencias Agrarias. Londrina: Universidade Estadual de Londrina (UEL), v. 30, n. 3, p. 655-660, 2009.