Circulating tumor cell isolation from clinical samples utilizing a lateral filter array microfluidic device

Nenhuma Miniatura disponível

Data

2019-01-01

Orientador

Coorientador

Pós-graduação

Curso de graduação

Título da Revista

ISSN da Revista

Título de Volume

Editor

Tipo

Trabalho apresentado em evento

Direito de acesso

Resumo

Isolation methods of circulating tumor cells (CTCs) usually rely on either immunoaffinity or size-based separation. However, immunoaffinity methods miss CTCs under-expressing surface markers of interest. Size-based methods miss CTCs with a size less than the filter geometry designed. We have developed a lateral filter array microfluidic (LFAM) device that integrates size-based separation with immunoaffinity-based isolation. We have demonstrated that the LFAM device improves CTC capture from blood samples of colorectal cancer patients when compared to a microfluidic device using either size-based filtration only or immunoaffinity alone.

Descrição

Idioma

Inglês

Como citar

23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019, p. 1514-1515.

Itens relacionados

Coleções