Are Brazilian cervids at risk of prion diseases?

Ribeiro Falcao, Caio Bruno; Nunes Freire Lima, Isabel Luiza de Melo; Barbanti Duarte, Jose Mauricio [UNESP]; Mendes de Oliveira, Joao Ricardo; Torres, Rodrigo Augusto; Wanderley, Artur Maia; Gomes da Cunha, Jose Eriton; Garcia, Jose Eduardo

Are Brazilian cervids at risk of prion diseases?

Arquivos

WOS000396024200008.pdf (469.97 KB)

Data

2017-01-01

Autores

Ribeiro Falcao, Caio Bruno

Nunes Freire Lima, Isabel Luiza de Melo

Barbanti Duarte, Jose Mauricio

Mendes de Oliveira, Joao Ricardo

Torres, Rodrigo Augusto

Wanderley, Artur Maia

Gomes da Cunha, Jose Eriton

Garcia, Jose Eduardo

Editor

Taylor & Francis Inc

Tipo

Artigo

Direito de acesso

Acesso aberto

Resumo

Prion diseases are neurodegenerative fatal disorders that affect human and non-human mammals. Chronic Wasting Disease (CWD) is a prion disease of cervids regarded as a public health problem in North America, and polymorphisms at specific codons in the PRNP gene are associated with this disease. To assess the potential CWD susceptibility of South American free-ranging deer, the presence of these polymorphisms was examined in Mazama gouazoubira, Ozotoceros bezoarticus and Blastocerus dichotomus. Despite the lack of CWD reports in Brazil, the examined codons (95, 96, 116, 132, 225, and 226) of the PRNP gene showed potential CWD susceptibility in Brazilian deer. Low abundancy of deer in Brazil possibly difficult both CWD proliferation and detection, however, CWD surveillance may not be neglected.