GENETIC INSTABILITY IN NERVE SHEATH CELL TUMORS

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dc.contributor.authorRainho, C. A.
dc.contributor.authorCasartelli, C.
dc.contributor.authorBarbierineto, J.
dc.contributor.authorRogatto, Silvia Regina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:23:46Z
dc.date.available2014-05-20T15:23:46Z
dc.date.issued1995-09-01
dc.description.abstractAfter in vitro culture, we analyzed cytogenetically four acoustic nerve neurinomas, one intraspinal neurinoma and one neurofibroma obtained from unrelated patients. Monosomy of chromosomes 22 and 16 was an abnormality common to all cases, followed in frequency by loss of chromosomes 18 (three cases) and chromosomes 8, 17 and 19 (two cases). Trisomy of chromosome 20 was also detected in two cases. Structural rearrangements were detected at low frequencies, with del(10)(p12) being present in two cases. In addition, we observed cell subpopulations showing a certain degree of genetic instability, reflected by the presence of polyploid cells with inconsistent abnormalities, endoreduplications and telomeric associations resulting in dicentric chromosomes. It is probable that these cytogenetic abnormalities represent some kind of evolutionary advantage for the in vitro progression of nerve sheath tumors.en
dc.description.affiliationUNIV ESTADUAL PAULISTA JULIO DE MESQUITA FILHO,DEPT GENET,SERV ACONSELHAMENTO GENET,BOTUCATU,SP,BRAZIL
dc.description.affiliationUnespUNIV ESTADUAL PAULISTA JULIO DE MESQUITA FILHO,DEPT GENET,SERV ACONSELHAMENTO GENET,BOTUCATU,SP,BRAZIL
dc.format.extent459-467
dc.identifierhttp://www.gmb.org.br/Revistas/V18/v18a071.pdf
dc.identifier.citationRevista Brasileira de Genetica. Ribeirao Pret: Soc Brasil Genetica, v. 18, n. 3, p. 459-467, 1995.
dc.identifier.fileWOSA1995TA98500017.pdf
dc.identifier.issn0100-8455
dc.identifier.lattes8814823545159504
dc.identifier.orcid0000-0002-0285-1162
dc.identifier.urihttp://hdl.handle.net/11449/34475
dc.identifier.wosWOS:A1995TA98500017
dc.language.isoeng
dc.publisherSoc Brasil Genetica
dc.relation.ispartofRevista Brasileira de Genética
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleGENETIC INSTABILITY IN NERVE SHEATH CELL TUMORSen
dc.typeArtigo
dcterms.licensehttp://www.gmb.org.br/copyright.html
dcterms.rightsHolderSoc Brasil Genetica
unesp.author.lattes8814823545159504[1]
unesp.author.orcid0000-0002-0285-1162[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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