Distribution of rabies virus in infected mice, vaccinated and submitted to P-acnes as immunomodulator

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dc.contributor.authorMegid, Jane [UNESP]
dc.contributor.authorCremonini, D. N.
dc.contributor.authorLeomil, H.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:38:11Z
dc.date.available2014-05-20T13:38:11Z
dc.date.issued2002-07-01
dc.description.abstractThe lethality and distribution of rabies virus were evaluated in swiss mice experimentally infected with street rabies virus, vaccinated and submitted to immunomodulation by P. acnes (formerly Corynebacterium parvum). The animals were sacrificed at different times,when the different tissues were collected and submitted to fluorescent antibody test (FAT) and mouse inoculation test (MIT). The group submitted to vaccination and P. acnes treatment presented a percentage of survival superior to that observed in infected mice only treated with P. acnes. Control infected animals had the lowest survival rates. The distribution of rabies virus in spleen of infected mice, vaccinated and submitted to P. acnes was superior to that verified in infected mice not treated with P. acnes. The increased survival correlated with the distribution of rabies virus in lymphoid tissues, could be interpreted as the consequence of P. acnes activity on macrophages. The results suggest the role of macrophages against rabies virus infection in mice and the importance of vaccination in the post expositive treatment of rabies. (C) 2002 Published by Elsevier B.V. Ltd.en
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Dept Vet Hyg & Publ Hlth, Fac Med Vet, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Dept Vet Hyg & Publ Hlth, Fac Med Vet, BR-18618000 Botucatu, SP, Brazil
dc.format.extent237-248
dc.identifierhttp://dx.doi.org/10.1016/S0147-9571(02)00010-3
dc.identifier.citationComparative Immunology Microbiology and Infectious Diseases. Oxford: Pergamon-Elsevier B.V., v. 25, n. 4, p. 237-248, 2002.
dc.identifier.doi10.1016/S0147-9571(02)00010-3
dc.identifier.issn0147-9571
dc.identifier.urihttp://hdl.handle.net/11449/13250
dc.identifier.wosWOS:000176321900004
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofComparative Immunology Microbiology and Infectious Diseases
dc.relation.ispartofjcr1.920
dc.relation.ispartofsjr0,877
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectrabiespt
dc.subjectimmunomodulatorpt
dc.subjectP. acnespt
dc.subjectpathogenesispt
dc.titleDistribution of rabies virus in infected mice, vaccinated and submitted to P-acnes as immunomodulatoren
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.orcid0000-0002-6540-7157[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt

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