Potentiometric determination of alendronate in pharmaceutical formulations

Nenhuma Miniatura disponível

Data

2004-01-01

Orientador

Coorientador

Pós-graduação

Curso de graduação

Título da Revista

ISSN da Revista

Título de Volume

Editor

Instytut Chemii Fizycznej Pan

Tipo

Artigo

Direito de acesso

Acesso restrito

Resumo

A simple, precise, fast and low-cost potentiometric method for alendronate determination in pharmaceutical formulations has been proposed. Alendronate present in tablets at the known concentration was potentiometrically titrated in an aqueous solution using a combined glass electrode coupled with an autotitrator. Determination limit of alendronate was 20.0 mug mL(-1). In the presence of common excipients, such as lactose, microcrystalline cellulose, glucose, croscarmellose sodium, starch, talc, magnesium stearate and titanium dioxide no interferences were observed. The method proposed was validated by determining alendronate in various dosage forms. The average RSD was 0.75%.

Descrição

Idioma

Inglês

Como citar

Chemia Analityczna. Warsaw: Instytut Chemii Fizycznej Pan, v. 49, n. 3, p. 351-357, 2004.

Itens relacionados

Financiadores