Anti-apoptotic effects of decyl gallate on the induction of apoptosis in A549 pneumocytes by Paracoccidioides brasiliensis gp43

Bernardi, Thais [UNESP]; De Fátima Da Silva, Julhiany [UNESP]; Vicentin, Juliana [UNESP]; De Oliveira, Haroldo Cesar [UNESP]; Assato, Patricia Akemi [UNESP]; Marcos, Caroline Maria [UNESP]; De Paula E Silva, Ana Carolina Alves [UNESP]; Da Silva, Rosangela Aparecida Moraes [UNESP]; Regasini, Luis Octávio [UNESP]; Silva, Dulce Helena Siqueira [UNESP]; Da Silva Bolzani, Vanderlan [UNESP]; Fusco-Almeida, Ana Marisa [UNESP]; Mendes-Giannini, Maria José Soares [UNESP]

Anti-apoptotic effects of decyl gallate on the induction of apoptosis in A549 pneumocytes by Paracoccidioides brasiliensis gp43

Arquivos

2-s2.0-85032208982.pdf (735.39 KB)

Data

2017-11-01

Autores

Bernardi, Thais

De Fátima Da Silva, Julhiany

Vicentin, Juliana

De Oliveira, Haroldo Cesar

Assato, Patricia Akemi

Marcos, Caroline Maria

De Paula E Silva, Ana Carolina Alves

Da Silva, Rosangela Aparecida Moraes

Regasini, Luis Octávio

Silva, Dulce Helena Siqueira

Tipo

Artigo

Direito de acesso

Acesso aberto

Resumo

Apoptosis is considered an escapemechanism from the host immune system for the fungus Paracoccidioides spp, and it serves as a vehicle for entry into macrophages without stimulating microbicidal activities. Recently, gp43 of P. brasiliensis was demonstrated to be involved in this process. Therefore, as a new therapeutic alternative, it is very important to study compounds that could reduce the modulation of the induction of apoptosis caused by this fungus. Decyl gallate (G14) is a known antifungal compound, and we decided to investigate its anti-apoptotic properties. Our results demonstrate that G14 was effective against apoptosis induced by gp43, as observed in epithelial cells, and led to a reduction in DNA damage, Bak down-regulation and Bcl-2 up-regulation. Together, these data show that G14 presents promising anti-apoptotic activity.